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Did Michael Jackson die of a Propofol overdose?

 

On Thursday, June 25, 2009, Michael Jackson was pronounced dead by physicians at UCLA Medical Center.  First came disbelief.  Then came the questions, particularly after the L.A. Coroner announced Jackson did not die of a stroke, heart attack, pulmonary embolism or some other sudden affliction which might strike down an otherwise healthy, 50 year old man.   And so, nearly from the day of Jackson's death, murmurs of a drug overdose arose.  Those murmurs became outright speculation when U.S. Marshals seized bags of medications from Jackson's home.  Among the medicines and paraphernalia was the drug Propofol (brand name Diprivan), a powerful, injectable sedative found only in operating rooms and Intensive Care Units.

Until the toxicology reports return in several weeks, we cannot be sure what killed Jackson, but the first sign of drug involvement came from the 911 call itself.  Jackson's personal physician, Dr. Conrad Murray, told police he found the singer, unresponsive in his bedroom, at around 11:30 A.M. on June 25th.  Instead of phoning 911 immediately, Dr. Murray apparently tried to revive his patient himself, performing CPR for nearly an hour before paramedics were called.  According to forensic pathologist Dr. Michael Baden, "The whole concept of prescription drug abuse (would explain) the confusion at the scene." 

Then there are the testimonies from those close to Jackson about escalating drug use, probably prescription pain killers such as Oxycontin and possibly IV medications.  "I never witnessed him actually taking drugs but I knew they were there... and Uri [Geller, a Jackson friend] confiscated injection equipment from his room.", said Matt Fiddes, a bodyguard and friend of Jackson.  Fiddes, however, insists Jackson ,"...was not a druggie.....It was prescription drugs and painkillers from what I understand."  Jackson's dependency on these drugs may stem from an incident in the 1980's, when his head was badly burned during filming of a commercial. 

Finally there is the most recent revelation by a nurse close to Jackson, her claim borne out when law enforcement officials reportedly seized bags of medications and paraphernalia from Jackson's L.A. home.  Just days before his death, Jackson phoned nurse Cherilyn Lee, all but begging her for the drug Propofol to alleviate his insomnia.  "I said, ' Tell him he needs to go [to] the hospital...right away.' ", but Jackson didn't heed the nurse's advice.  Instead, he apparently convinced someone else to obtain the medication since it was among the cache seized and taken into evidence.

Propofol has only one legitimate use: induction of what amounts to a very deep sleep preparatory to surgery.  It is not prescribed on an out-patient basis, it is not given for insomnia. ("Using this drug for insomnia is sort of like using a shotgun to kill an ant." - Dr. Howard Nearman, Department Chairman of Anesthesia at University Hospitals Case Medical Center in Ohio.)  Frankly, the sole way it could wind up in Jackson's home would be through illegal means. 

Propofol is a sedative-hypnotic, available only in injectable form.  It is rarely given as a single dose, but instead administered as a controlled infusion.  A direct, IV shot of Propofol dramatically increases the risk of hypotension, airway obstruction, and blood oxygen desaturation.  Unlike opiates such as Demerol or Oxycontin, Propofol has no antidote.  An opiate overdose is often treated by administering Narcan, an opioid antagonist.  Narcan immediately blocks the opioid, often bringing the patient back to consciousness within minutes, if not seconds.  

In a hospital or operating room, a Propofol overdose is treated by immediately ceasing the drug's infusion, then beginning respiratory and cardiac support while other drugs are administered to increase blood pressure, helping re-perfuse tissues with blood and oxygen until the drug is eliminated by the body and the patient regains consciousness.  The time required to clear Propofol depends mainly on the amount of Propofol given and over what period of time as well as the ability of the patient's liver and kidneys to metabolize and eliminate the drug.

If someone did, indeed, give Jackson a shot of Propofol on June 25th, it explains the singer's quick lapse into unconsciousness. The drug would have entered his blood stream and reached his brain within minutes. Soon after, his heart would slow, his organs (including his brain) becoming deprived of blood and the oxygen it carries, his breathing becoming more and more shallow until ceasing altogether.  If the physician found Jackson even an hour after that shot was given, it is unlikely anything could have saved the singer.  Our brains cannot tolerate a lack of oxygen for long.  Barring exigent circumstances (such as extreme cold), 10 minutes without oxygen means death.

How Jackson obtained his medications and the role (if any) physicians played in his use of them is currently under investigation.  All prescriptions are maintained on a computer data base and the original copies stored for several years.  It is these records investigators will be scrutinizing over the coming weeks and months.  It's a daunting task, compounded by the practice of using aliases when celebrities are involved.  It may very well be years before we know the whole picture. 

Whatever the exact circumstances may be, one thing is certain: a man of great talent, his career begun over 40 years ago as a child with extraordinary charm and presence, that man is gone.

Please, if you have any questions or comments, feel free to leave them on this website or email me at christianaki1@hotmail.com

 

 

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By

Chicago Health Care Examiner

In 1997, Christiana graduated from the University of Illinois, School of Pharmacy, going on to practice in a range of health care settings. This...

Comments

  • tammypierce 2 years ago
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    i believe that someone gave Michael Jackson an overdose of medications of Didvan that cause his heart to stop. I miss him already because he was a good singer and he was cute, my heart goes out to his family beside Janet which she was his favorite person that he care about beside his mom and dad. They were cute kids anyway. All the Jackson Boys are cute.

  • jasom 12 months ago
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    jiiiizzzzzz

  • Lucy 2 years ago
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    Michael Jackson's former chef, Douglas B. Jones, claims that he saw Dr. Murray leave the kitchen several times with waist-high oxygen tanks. He also said that Dr. Murray was often at MJ's house 5 nights per week. You can watch his interview on radaronline.com. He is a renown California chef, so I don't think that we would be spreading rumors for fame's sake. I'm starting to wonder if Dr. Murray ever intended to revive MJ and waited to call 911 because he was hoping that Diprivan would disappear from his system by the time he was hospitalized.

  • mary 2 years ago
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    i cant believe it that tht micheal jackson has died he is my best singer i just used to love him.

  • Alexis 2 years ago
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    OMG i cant belive that he died

  • squrish 2 years ago
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    The fact that the world has lost a great singer we all know. How we lost him, will we ever know? There has to be someone that was close to him besides his doctor that knew of his drug habbits, why cant they just be great friends like they claimed to MJ the were and come forward with the truth. Things would be much eaiser on his children to close the ends now.

  • MiaMouth 2 years ago
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    How about the fact that he did things that was illegal... he may not have been convicted of wrongfully touching children but if he was innocent why did he pay those families off. And I don’t want to hear that it was easier that way… These are children we are talking about!!!!!!!!!!! Lets not forget that among the medicines and paraphernalia found in his home was the drug Propofol (brand name Diprivan), a powerful, injectable sedative found only in operating rooms and Intensive Care Units. This is NOT LEGAL to have in your home!!!!!!!!

  • Alyssa Hall 2 years ago
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    Michael Jackson death was not an accident he so called doc. killed him. It was told that they found drugs in his house........ but was there any sign of drugs in his body. Michael Jackson was killed and his doc. needs to go to PRISON FOR LIFE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
    This war whit Michaels Deat is not over for a lot of us in clueding ME!!!!!!!!!!!!!!! Justic will be served!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

    That is all.

  • jasmine 2 years ago
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    i cant believe that my bet singer he was my best friend i love you

    R.I.P

  • jasmine 2 years ago
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    I LOVE YOU AND I LOVE YOU AND R.I.P

  • a kid 2 years ago
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    His Doctor should have called 911 first then try to revive him

  • Deven 2 years ago
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    No one knows what really happin in that room but the doc. and Micheal Jacksons family diserves some answers we all do, I wish the best for M.J's family i just wish the truth comes out soon we all know who did it.It was'nt an acsadintal death.Don't worry Janet and the rest of the brothers , sisters ,M.J's kides ,and mom and dad you all are in my prayers..

  • Margy 2 years ago
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    He could have had 10 more years of hot songs the fans were robbed of that.The doctor should be held responsible for the medicine that came from him. Love and prayers to his childred and family.

  • ICU RN 2 years ago
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    "Propofol has only one legitimate use: induction of what amounts to a very deep sleep preparatory to surgery."

    Propofol is used for two reasons:
    a) the induction and maintenance of anesthesia
    b) the sedation of intubated, mechanically ventilated patients in intensive care units

    Obviously, Mr. Jackson was not mechanically ventilated, but your medication information is inaccurate. As a side note, the report of oxygen bottles in no way indicates mechanical ventilation. It would indicate supportive oxygen use. He was not mechanically ventilated.

  • annie jackson 2 years ago
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    i believe the the oh so called doctor gave michael jackson the overdose of medications!!!!!!!!!!!! we will miss you michael we will think about you for the rest of your life!!!!!!!!!!!!! becuz you where and are the best. know one will be better then you.

  • kevin 2 years ago
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    R.I.P MJ

  • some kid 2 years ago
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    hey we all love u mj and everyone say r.i.p mj

  • alicia 2 years ago
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    R.I.P MICHAEL JACKSON

  • shafer 2 years ago
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    all of that sounds beleave able. true probley the overdose on med.s they found 60 diffrent kinds of pills to and some bud. which i know that wasnt the reason haha that sum good stuff to do that or he was just burnt up to a crisp and couldnt take inymore bull crap from everybody and ended his own life which is possible whos knows well hes dead now and you nobody can bring him back hes gone forever later man!!!!!!!!!!!!!!!!!!!!!!!

  • ethan caselberry 2 years ago
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    well i think he died bc he was g a y to much butt s e x he loved his little boys as we all know i was one of his favorit custermers hahahah yes i thinks it funny and if we have inybody that wants to talk in person just call me on 1580.444.3658 my mom will probley answer the phone but as for me ethan il probley be squirtn a load on the computer

  • ketchie 2 years ago
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    micheal died as a great man and he is a good dancer of course. and i just wanna say that he reakky is the king of pop

  • kiwi 2 years ago
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    nobody really knows how he died but i do he was attaked by a monster it was scary i was there ahhhhhhhhhhh! talk to the monster for more information.

  • kiwi 2 years ago
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    monster killed him it was scary i was there

  • kj 2 years ago
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    I am sad that he died but the good lord wanted him home.I mean what is really crazy that no one really honestly paid this much attention to him but I guess its because he is dead I will miss him

  • Diana 2 years ago
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    i heard that his personal doctor was the one that killed him , and sometimes about admitting it .
    anyways , R.I.P Michael Jackson . You will always be remembered .

  • *Love Hurts* 2 years ago
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    We all love u Michael Jackson.Rest in peace.love u.

  • Aliyah 2 years ago
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    U will always be remembered.R.I.P MJ

  • desstiny 2 years ago
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    i hope your famly will be allright rest in peace M.J.

  • denzel aungst 2 years ago
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    i loved little mikey's songs. what people say ain't true. he was da best. he has the best songs ever. i will miss him really much. go with God michael and rest in peace.

  • denzel aungst 2 years ago
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    (prayer to michael) Dear lord please be with michael only you know what was best for him and only you know if he did all the stuff so be with his family and watch and protect them as you do me AMEN.

  • wolfspade 2 years ago
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    I feel like talking soo...hi im wolfspade did you know michael jackson died on June,25th/2009, that wasnt long ago, I like pie... Mmmm...

  • Collin 2 years ago
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    Sad. Just a true genius, musician, and most of all, person. R.I.P. You will be remembered

  • nyeshia j 2 years ago
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    Why Did He Die/ Because the doctor killed him why would u do CPR for a whole hour u no if he did nt wake up he was dead sho u should have called 911 so after a hour wat did u do wat whould u do after u did CPR for an hour I would have stop at 10 mints and would have rushed and called 911 tat doctor killed him so thay need to soo tat dr he was all redy dead when u walked in the room so y u bid nt call911 so there for he killed him

  • Lindsay Sifrit 2 years ago
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    God Bless Michael. Okay...So I just saw "This Is It" and I have to say this...Michael Jackson is THE SEXIEST most talented, most gifted man to ever be on a stage. When you can touch peoples lives whom you've never even met your a gift from God. That man was BRILLIANT in every aspect of the word. I love you Michael! RIP! How many times in your life can you honestly say you love someone their personality the way they touch your heart...when you haven't even met them! Not very many! Everyone should see that movie! I love you Michael. RIP

  • kely 2 years ago
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    I like mj songs but im sad beacause he died. So once and for all mj is the best rip mj

  • Kay-Kay 2 years ago
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    WOw if u dont like mj then go die seriously wow u guys are jerks he wasnt gay!!1

  • Kayla 2 years ago
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    Hi maddiiiiii

  • Maddie 2 years ago
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    Haiiiii Kaylaaaaaaaaaaaaaaa!!!! i lurv MJ! DONT YOU!!

  • Kayla 2 years ago
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    TOttaly WOW Peaple are meandont you Think madie?

  • Maddie 2 years ago
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    all these ppl are mean to MJ right Kayla!! NOT COOLLLL!

  • Matt johnson 2 years ago
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    Hii Im gay

  • paul 2 years ago
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    i like maddie

  • Kayla 2 years ago
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    WOW MAtt Ur a jerk but n e way were talking about mj!!!~!!!!!

  • maddie 2 years ago
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    thank you!

  • Matt johnson 2 years ago
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    I LOVE ?Kayla M...?

  • kayla 2 years ago
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    wow matt!!!!!! ur weird
    hey paul awwweeee u like maddie<-

  • kayla 2 years ago
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    Maddie u a funny goose!!

  • billybobjoe?? 2 years ago
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    i luvvvvvv mj he is my savior for the rest if my life in luuuuuuuvvvv himmmm im not kiddding i made a furneral 4 him at my house in the bathroommmmm?

  • kayla 2 years ago
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    HI JOey

  • billybobjoe?? 2 years ago
    Report Abuse

    you cant touch my baby mikey jjjj iwilll luve em 4 life

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