Prior to the delay Albuquerque had rallied to tie the game 2-2. After the delay, Las Vegas pulled away for a 6-3 victory to split the two games.
"We knew it was coming, it was just one of those things where you were hoping it was going to come light enough that you could play through it," manager Damon Berryhill said. "It got us pretty good for 20 minutes or so."
Matt Magill (4-5) came on in relief of starter Zach Lee following the delay in the fifth inning. Opposing reliever Miguel Socolovich (2-2) reached on a fielding error by Magill and went to third on Matt den Dekker's double to right field.
Daniel Muno's groundout to second base was enough to score Socolovich and put the 51s (52-38) ahead for good on the Isotopes (41-49). Magill gave up just that unearned run in two innings but it was enough for the loss.
"Matt came in and did a decent job for us," Berryhill said. "Offensively we just couldn't get anything really going after that rain."
In the seventh and final inning, Wilmer Flores blasted a three-run homer off Pedro Baez to put Las Vegas ahead 6-2. It was Flores' 10th home run of the season and his fourth in three games so far in Albuquerque.
"Yeah, he's been swinging it well, obviously," Berryhill said. "But the balls he's hit, if you look at all of them, they've all been middle plate, mid-thigh. We just have to do a better job making better pitches."
Pinch hitter Mike Baxter led off the Isotopes' half of the seventh with a triple to right-center. Trayvon Robinson grounded out to shortstop, which was enough to score Baxter, but that would be it as Brian Cavazos-Galvez popped up and Jamie Romak grounded out.
"It was a tough ballgame," Berryhill said. "Pedro made the one mistake, gave up the three-run jack."
Rehabbing Los Angeles Dodgers left fielder Carl Crawford played in the four innings before the rain delay. He had a nice leaping catch at the warning track to rob Allan Dykstra of a hit in the first inning.
Crawford singled, went to third on Romak's single and scored on Brock Peterson's double in the bottom of the frame. The veteran showed no signs of trouble with his sprained left ankle.
"He said he's been feeling fine," Berryhill said. "Looked strong going first to third. He said he's just got to test it. Unfortunately the rain came and cut his night a little bit short. But he showed that he looks healthy early on for sure. He'll get more action (Sunday)."
Albuquerque and Las Vegas will wrap up the series Sunday at 6:05 p.m. The Isotopes will start right-hander Red Patterson (3-6, 4.69 ERA) against 51s right-hander Noah Syndergaard (6-4, 5.70), who is ranked as the New York Mets' top prospect by Baseball America.