Here’s how using two of the most popular twitter clients Seesmic Desktop and TweetDeck.
http://www.youtube.com/watch?v=UoH3yisoHr8
The next step is to block and un-follow the Dweebs (I’ll do both AFTER I first report them).
You can also report them manually by sending a direct message to @spam with the offender's @name and a link to the offending tweet (Example: d spam @MoneyMome13 http://twitter.com/MoneyMome13/statuses/4428236145)
Twitter says that reported Spammers will have their accounts removed and even blocked at the I.P. level.
Take that you nasty Spammers! Yay for Twitter!