MICHAEL JACKSON (5 nominations): Artist of the Year; Pop/Rock - Favorite Male Artist, Favorite Album ('Number Ones'); Soul/R&B - Favorite Male Artist, Favorite Album ('Number Ones').
- MICHAEL JACKSON (5 nominations): Artist of the Year; Pop/Rock - Favorite Male Artist, Favorite Album ('Number Ones'); Soul/R&B - Favorite Male Artist, Favorite Album ('Number Ones').
- TAYLOR SWIFT (6): Artist of the Year; Pop/Rock - Favorite Female Artist, Favorite Album ('Fearless'); Country - Favorite Female Artist, Favorite Album ('Fearless'); Adult Contemporary - Favorite Artist.
- LADY GAGA (3): Artist of the Year; Pop/Rock - Favorite Female Artist, Favorite Album ('The Fame').
- EMINEM (4): Artist of the Year; Pop/Rock - Favorite Male Artist; Rap/Hip-Hop - Favorite Male Artist, Favorite Album ('Relapse').
- KINGS OF LEON (3): Artist of the Year; Pop/Rock - Favorite Band, Duo or Group; Alternative Rock - Favorite Artist.
- T.I. (3): Pop/Rock - Favorite Male Artist; Rap/Hip-Hop - Favorite Male Artist, Favorite Album ('Paper Trail').
- BEYONCE (3): Pop/Rock - Favorite Female Artist; Soul/R&B - Favorite Female Artist, Favorite Album ('I Am... Sasha Fierce').
- THE BLACK EYED PEAS (3): Pop/Rock - Favorite Band, Duo or Group; Soul/R&B - Favorite Band, Duo or Group, Favorite Album ('The E.N.D').
- NICKELBACK (1): Pop/Rock - Favorite Band, Duo or Group.
- JAY-Z (2): Rap/Hip-Hop - Favorite Male Artist, Favorite Album ('Blueprint 3').
- RASCAL FLATTS (2): Country - Favorite Band, Duo or Group, Favorite Album ('Unstoppable').
- ZAC BROWN BAND (2): Country - Favorite Band, Duo or Group, Favorite Album ('Foundation').
- DARIUS RUCKER (1): Country - Favorite Male Artist.
- JASON ALDEAN (1): Country - Favorite Male Artist.
- KEITH URBAN (1): Country - Favorite Male Artist.
- CARRIE UNDERWOOD (1): Country - Favorite Female Artist.
- REBA MCENTIRE (1): Country - Favorite Female Artist.
- SUGARLAND (1): Country - Favorite Band, Duo or Group.
- MILEY CYRUS (2): Soundtracks - Favorite Album ('Hannah Montana: The Movie' & 'Hannah Montana 3')
- TWILIGHT (1): Soundtracks - Favorite Album ('Twilight Motion Picture Soundtrack')
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