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Bush to announce expanded bank bailout details- The Bush administration plans to spend an initial $250 billion of the $700 billion bailout buying stock in private banks, greatly expanding protections for the U.S. financial system out of deep concern for the faltering economy, industry and government officials said Monday night. President Bush planned to announce the details Tuesday morning.
McCain: Lewis' remarks on campaign tone are unfair- John McCain said Monday that it was unfair for Rep. John Lewis to compare the negative tone of the Republican presidential campaign to the atmosphere a segregationist fostered in the 1960s.
- Democratic U.S. Rep. Tim Mahoney, married with a child, declined to say Monday whether he had carried on an affair with a former aide and paid to keep her quiet, then called for an investigation by the House ethics committee into his own conduct.
2nd out-of-state teen dropped at Omaha hospital- A Michigan mother drove roughly 12 hours to Omaha, so she could abandon her 13-year-old son at a hospital under the state's unique safe-haven law, Nebraska officials said Monday.
Johnston speaks about Bristol Palin, Obama, baby- Levi Johnston, who's having a baby with Gov. Sarah Palin's daughter, can't believe all the things he's hearing. No, he wasn't held against his will on the campaign trail. No, he's not being forced into a shotgun wedding with 17-year-old Bristol Palin.
Therapy helps hard-to-transplant get a new kidney- Nearly one in three patients who need a kidney transplant may never get one because their bodies are abnormally primed to attack a donated organ. Now doctors are trying new ways to outwit the immune system and save more of those so-called "highly sensitized" patients - often with kidneys donated by living donors, considered the optimal kind.
Doctor orders Janet Jackson to postpone tour- The doctor has again ordered Janet Jackson to postpone a return to her "Rock Witchu" tour. Jackson was scheduled to resume her tour Monday night at the Turning Stone Resort in New York after canceling a show over the weekend in Connecticut. A message posted on the resort and casino's Web site stated the show had been canceled at the advice of Jackson's doctor.
Prosthetic eye gives horse a shot at show career- A miniature horse has been given a second chance for a career as a show horse - thanks to a prosthetic eye. The 65-pound horse, named KBuck, was born June 1 at Lil Chums Miniature Horse Farm in Lawton and lost its eye a few days after birth. Owner Kelsey Chumbley, 12, said she suspects the young horse was the victim of a swift kick from its mother.
Rays bash Red Sox 9-1 to take 2-1 series lead- B.J. Upton, Evan Longoria and the rest of the Tampa Bay Rays are bashing their way through their first trip to the playoffs. Upton and Longoria homered off a suddenly shaky Jon Lester, and the power-packed Rays cleared the Green Monster four times to beat the Boston Red Sox 9-1 Monday for a 2-1 lead in the AL championship series.
BiPar Genomic Biomarker Data Demonstrate Overexpression of PARP-1 Gene in Multiple Cancer Types
SAN FRANCISCO
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The results were presented at the American Association for Cancer
Research-National Cancer Institute-European Organization for Research and
Treatment of Cancer (AACR-NCI-EORTC) International Conference on Molecular
Targets and Cancer Therapeutics in
"These results allow us to focus our clinical development plan for BSI-201
by targeting tumors types that have the greatest probability of clinical
success," said BiPar Executive Vice
BiPar researchers used the Gene Logic Inc. BioExpress(R) System database to analyze PARP-1 gene expression in all types of primary human cancer and compared the results to normal counterpart tissue. PARP expression was above the 95 percent upper confidence limit for normal tissue in ovarian cancer, intraductal breast cancer, lung cancer and uterine cancer. In contrast, prostate tumor tissue showed minimal PARP overexpression.
BSI-201 has been tested as both monotherapy and in combination with standard therapy in Phase 1 studies in patients with solid tumors. BiPar is preparing to initiate Phase 1b and Phase 2 trials of BSI-201 in several specific tumor types guided largely by gene expression data.
About PARP
PARP-1 plays a central role in cell proliferation and in DNA repair. BiPar's novel, proprietary PARP inhibitors are a new generation of drug candidates that show promising activity and a favorable toxicity profile. Preclinical studies suggest the drugs selectively inhibit cell proliferation and are active against a broad range of tumor types.
About BiPar Sciences
BiPar Sciences Inc. (http://www.biparsciences.com) is a clinical-stage biopharmaceutical company developing and commercializing a pipeline of novel, tumor-selective drugs designed to meet the significant unmet needs of cancer patients.
BioExpress(R) is a registered trademark of Gene Logic Inc.
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