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McCain, Obama clash over economic crisis- Barack Obama and John McCain clashed repeatedly over the causes and cures for the worst economic crisis in 80 years Tuesday night in a debate in which Republican McCain called for sweeping action by the government to directly shield many homeowners from mortgage foreclosure.
Analysis: Obama gains, McCain seeks game-changer- Barack Obama made strides toward easing voters' concerns about his candidacy in Tuesday night's debate. John McCain, despite raising pointed questions about his rival's readiness, didn't create the game-changing moment he'll need between now and Election Day.
AIG execs' retreat after bailout angers lawmakers- Days after it got a federal bailout, American International Group Inc. spent $440,000 on a posh California retreat for its executives, complete with spa treatments, banquets and golf outings, according to lawmakers investigating the company's meltdown.
- Hurricane Norbert strengthened into a powerful Category 2 storm over the Pacific Ocean and forecasters warned that it could reach Mexico's Baja California peninsula by the weekend.
300 suspected illegal immigrants caught in SC raid- Federal agents swept through a chicken processing plant Tuesday, detaining more than 300 suspected illegal immigrants, sending panicked workers running and screaming through the hallways. Worried relatives collected outside, fearful their loved ones would be deported.
- A U.S. military officer warned Pentagon officials that an American detainee was being driven nearly insane by months of punishing isolation and sensory deprivation in a U.S. military brig, according to documents obtained by The Associated Press.
- Will NASA's flagship mission to Mars fly next year? The space agency could decide as early as Friday whether to cancel, delay or proceed with plans to launch a nuclear-powered, SUV-size rover to the red planet.
Half-ton Mexican man dies after pleading for help- A 450-kilogram (990-pound), bedridden man who had appealed on Mexican television for help tackling his weight problem died Tuesday of heart failure, his family said.
Travis Barker thankful to be alive after jet crash- Former Blink-182 drummer Travis Barker, who always has been afraid of flying, says he's glad to be alive after suffering severe burns in a fiery plane crash last month.
Bosox-Rays renew rivalry, Manny in middle of NLCS- Exactly why the Boston Red Sox and Tampa Bay Rays tangle so much is hard to tell. Blame it on a high-and-tight pitch here, a hard slide there. Whatever, this much is true: The teams playing in the AL championship series sure get into a lot of scraps. "There's no hatred," injured Red Sox pitcher Curt Schilling insisted Tuesday in an e-mail to The Associated Press.
BiPar Announces Upcoming Data Presentations Demonstrating Progress on PARP Inhibitor Drug Pipeline for Cancer
Brisbane, Calif.
(Map)
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PARP is a novel, validated target for cancer treatment. PARP1 plays a central role in cell proliferation and in DNA repair. BiPar scientists will present results showing that PARP1 gene expression is significantly upregulated in many but not all tumor types. BiPar's novel, proprietary PARP inhibitors are members of a new generation of drug candidates that show promising activity and a favorable toxicity profile. Preclinical studies suggest the drugs selectively inhibit tumor cell proliferation and are active against a broad range of tumor types. BiPar is initiating Phase 1b and Phase 2 clinical trials of BSI-201, its lead PARP inhibitor, in several major cancers. That research program has been directed in large part by the molecular biomarker data being presented at these meetings.
"These findings will focus our efforts on those tumor types with the
greatest opportunity for clinical success," said
The schedule of presentations is as follows:
Title: The novel PARP-1 inhibitor, BSI-401, has antitumor activity
and potentiates oxaliplatin cytotopic activity in human
pancreatic cancer
When: Wednesday, Oct. 24, 2007, 12:30 p.m. PDT
Where: AACR-NCI-EORTC International Conference on Molecular Targets
and Cancer Therapeutics, Moscone West Convention Center, San
Francisco
Presenter: Davide Melisi, M.D., Department of Gastrointestinal Medical
Oncology, University of Texas M.D. Anderson Cancer Center
Title: PARP-1 gene over-expression in primary human cancers: A
potential marker for PARP inhibition.
When: Thursday, Oct. 25, 2007, 12:30 p.m. PDT
Where: AACR-NCI-EORTC International Conference on Molecular Targets
and Cancer Therapeutics, Moscone West Convention Center, San
Francisco
Presenter: Valeria Ossovskaya, Ph.D. Director of Preclinical
Development, BiPar
Title: The PARP1 gene is over-expressed in triple negative breast
cancer
When: Thursday, Nov. 15, 6 to 8 p.m. CEST
Where: EORTC-NCI-ASCO Annual Meeting on "Molecular Markers in
Cancer," Sheraton Brussels, Hotel & Towers, Brussels, Belgium
Presenter: Valeria Ossovskaya, Ph.D. Director of Preclinical Development,
BiPar
About BiPar Sciences
BiPar Sciences Inc. (http://www.biparsciences.com) is a clinical-stage biopharmaceutical company developing and commercializing a pipeline of novel, tumor-selective drugs designed to meet the significant unmet needs of cancer patients.
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