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House passes health care bill on close vote- In a victory for President Barack Obama, the Democratic-controlled House narrowly passed landmark health care legislation Saturday night to expand coverage to tens of millions who lack it and place tough new restrictions on the insurance industry. Republican opposition was nearly unanimous.
Some saw trouble ahead with Fort Hood shooter- In retrospect, the signs of Maj. Nidal Malik Hasan's growing anger over the U.S. wars in Iraq and Afghanistan seem unmistakable. But even people who worried his increasingly strident views were clouding his ability to serve the U.S. military could not predict the murderous rampage of which he now stands accused.
Ida becomes hurricane a 2nd time off Mexico coast- Ida grew into a hurricane for a second time as it roared over the Caribbean on a path that could take it between Mexico's resort-studded Yucatan Peninsula and Cuba before heading for the southern United States.
- Twenty years ago Monday, they danced atop the Berlin Wall, feet thudding on the cold concrete, arms raised in victory, hands clasped in friendship and giddy hope.
- A suicide bomber apparently targeting an anti-Taliban mayor struck a crowded market Sunday in northwest Pakistan, killing the mayor and 11 other people and injuring dozens, police said.
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Mickelson rallies to win HSBC Champions- Phil Mickelson won the HSBC Champions on Sunday by rallying against a familiar foe. Only it wasn't Tiger Woods.
Iontophoretic Drug Delivery System (IDDS) Containing Lidocaine and Epinephrine is Effective in Reducing Pain Associated With Insertion of an Intravenous Catheter in a Phase 2 Clinical Trial
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About the Trial:
The trial conducted was a Phase 2, double-blind, randomized, placebo-controlled, two-arm study evaluating the safety and efficacy of the administration of lidocaine and epinephrine using the IDDS to provide topical anesthesia in adults undergoing a venipuncture procedure. Eighty-nine (89) healthy volunteer subjects were treated at two clinical sites. The trial included subjects representing a wide range of ages and ethnicity. Subjects were randomized to receive an 8 minute administration of lidocaine plus epinephrine (Active arm) or epinephrine alone (Placebo arm) at the site of insertion of an intravenous catheter. After placement of the intravenous catheter, subjects evaluated their pain using the Visual Analog pain Scale (VAS) scoring system and were asked if they would use the IDDS again. Safety of the treatment was also monitored during the trial.
Results:
In the Per-Protocol population (including subjects completing 8 minutes of treatment) the mean Visual Analog pain Scale (VAS) results recorded by the subject following the venipuncture procedure were 16.4 mm for the Active treatment versus 24.0 mm for the Placebo treatment (p=0.0235). Therefore, the trial demonstrated statistically lower VAS scores for the Active group as compared to the Placebo group. In addition, more than 80% of the Active group reported pain elimination and willingness to undergo IDDS treatment again. The IDDS treatment was well tolerated, with no serious adverse event reported in any subject.
"This represents a major advancement for Dharma and the Transcu Group," said
Dharma has an end-of-phase 2 meeting scheduled with the Food and Drug Administration for this fall and plans to embark on pivotal Phase 3 trials in early 2010.
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