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- National Intelligence Director Mike McConnell says the terrorist group U.S. intelligence believes carried out last week's attack in Mumbai is the same one that attacked Mumbai trains in 2006.
Ga. Senate runoff could decide balance of power- Georgia's seemingly endless U.S. Senate campaign drew to a finish on Tuesday as polls closed on the hotly-contested race that will sway the balance of power in Washington.
Gates: Military looks to accelerate Iraq pullout- Defense Secretary Robert Gates signaled a willingness Tuesday to forge ahead with two key priorities for the incoming Obama administration: accelerating the U.S. withdrawal from Iraq and shutting down the Guantanamo Bay detention center.
- The divorce rate among soldiers and Marines increased last year as military marriages suffered continuing stress from America's two ongoing wars. There were an estimated 10,200 failed marriages in the active duty Army and 3,077 among Marines, according to figures obtained by the Associated Press for the budget year ended Sept. 30.
Nixon records show aides dishing dirt on critics- In Richard Nixon's time, all the president's men fretted about threats on every front: disquiet out on the streets, disloyalty inside the administration and trouble from political opponents who had to be discredited at any cost.
Chained teen shows up at Calif. gym; 2 arrested- A Girl Scout leader and her husband were arrested after an emaciated, terrified and nearly naked 17-year-old showed up at a gym with a chain locked to his ankle, saying he had just fled his captors, authorities said Tuesday.
Hudson in-law charged with killing 3 relatives- Jennifer Hudson's brother-in-law was charged with murder Tuesday in the shooting deaths of three of the actress's family members, including the 7-year-old son of his estranged wife.
Coleman pleads no contest to disorderly conduct- Gary Coleman has pleaded no contest to a disorderly conduct charge stemming from a September incident at a bowling alley. The 40-year-old former star of "Diff'rent Strokes" was ordered to pay a $100 fine in a Payson court Tuesday. He also pleaded no contest to a reckless driving charge, which will be waived if he doesn't have any other violations within a year.
- A message in a bottle tossed into the ocean off Barnegat Bay has turned up in North Carolina - 39 years later. The note was sealed in a Schaefer beer bottle. It was dated Aug. 17, 1969 and read: "If found notify the North Haledon Fire Co. 2."
NHL suspends Stars' Sean Avery for crude comments- The NHL suspended Dallas Stars forward Sean Avery indefinitely Tuesday for making a crude reference to former girlfriends while talking with reporters.
Nearly 60 New Studies of Oral Xeloda(R) (capecitabine) Featured at the 44th American Society of Clinical Oncology Annual Meeting
NUTLEY, N.J.
(Map)
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A U.S. abstract to be published in The 2008 ASCO Proceedings I, compares
the preclinical efficacy of an investigational, seven-days-on/seven-days-off
(7-on/7-off) Xeloda regimen versus the current standard Xeloda dosing of
fourteen-days-on/seven-days-off (14-on/7-off) in colorectal cancer. Findings
from this study appeared to indicate improved tumor growth inhibition with the
7-on/7-off Xeloda regimen; results support clinical testing of this regimen in
colorectal cancer patients. [See 2008 ASCO Proceedings I - An alternative
preclinical regimen of capecitabine ( C ) enhances single agent & combination
activity in a colorectal cancer xenograft model. (Lead Author:
Among ex-U.S. Xeloda abstracts being presented, 16 breast cancer and 15 colorectal cancer abstracts highlight Xeloda as the cornerstone of combination treatment. The remaining Xeloda abstracts are also ex-U.S. or sponsored by non-Roche entities.
About XELODA (capecitabine)
Xeloda is the only FDA-approved oral chemotherapy for both metastatic breast cancer and adjuvant and metastatic colorectal cancer. Inactive in pill form, Xeloda is enzymatically activated within the body; when it comes into contact with a naturally occurring protein called thymidine phosphorylase, or TP, Xeloda is transformed into 5-FU, a cytotoxic (cell-killing) drug. Because many cancers have higher levels of TP than does normal tissue, more 5-FU is delivered to the tumor than to other tissue.
A clinically important drug interaction between Xeloda and warfarin has been demonstrated; altered coagulation parameters and/or bleeding and death have been reported. Clinically significant increases in prothrombin time (PT) and INR have been observed within days to months after starting Xeloda, and infrequently within one month of stopping Xeloda. For patients receiving both drugs concomitantly, frequent monitoring of INR or PT is recommended. Age greater than 60 and a diagnosis of cancer independently predispose patients to an increased risk of coagulopathy.
Xeloda is contraindicated in patients who have a known hypersensitivity to 5-fluorouracil, and in patients with known dihydropyrimidine dehydrogenase (DPD) deficiency. Xeloda is contraindicated in patients with severe renal impairment. For patients with moderate renal impairment, dose reduction is required.
The most common adverse events (greater than or equal to 20%) of Xeloda monotherapy were diarrhea, nausea, stomatitis and hand-foot syndrome. As with any cancer therapy, there is a risk of side effects, and these are usually manageable and reversible with dose modification or interruption.
About Roche
Hoffmann-La Roche Inc. (Roche), based in
All trademarks used or mentioned in this release are protected by law.
Contacts: Ginny Valenze
Roche
Office: 973-562-2783
Cell: 973-943-9219
Virginia.Valenze@roche.com
Daphne Hoytt
Manning Selvage & Lee
Office: 212-468-3558
Cell: 917-406-2779
Daphne.Hoytt@mslpr.com
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