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Additional or updated data beyond the information submitted in the abstracts may be included in the following presentations at ASCO:
Ipilimumab Presentations in Melanoma -- "Antitumor response and new lesions in advanced melanoma patients on ipilimumab treatment" (Abstract #3020, Developmental Therapeutics: Immunotherapy Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Friday, May 30, 2008. -- "Long-term survival of patients with advanced melanoma who received ipilimumab administered at 10mg/kg every 3 weeks for 4 doses (induction dosing)" (Abstract #3018, Developmental Therapeutics: Immunotherapy Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Friday, May 30, 2008. -- "Potential immune biomarkers of gastrointestinal toxicities and efficacy in patients with advanced melanoma treated with ipilimumab with or without prophylactic budesonide" (Abstract #3022, Developmental Therapeutics: Immunotherapy Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Friday, May 30, 2008. -- "Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody" (Abstract #3008, Developmental Therapeutics: Immunotherapy Session) - Oral presentation beginning at 4:30 p.m. local time one Saturday, May 31, 2008. -- "Effect of prior treatment status on the efficacy and safety of ipilimumab monotherapy in treatment-naive and previously treated patients with advanced melanoma" (Abstract #9055, Melanoma Session) - Poster presentation from 2:00 p.m. to 6:00 p.m. local time on Saturday, May 31, 2008. -- "An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy" (Abstract #9063, Melanoma Session) - Poster presentation from 2:00 p.m. to 6:00 p.m. local time on Saturday, May 31, 2008. -- "Model-based evaluation of ipilimumab dosage regimen in patients with advanced melanoma" (Abstract #9073, Melanoma Session) - Poster presentation from 2:00 p.m. to 6:00 p.m. local time on Saturday, May 31, 2008. -- "Safety and efficacy of ipilimumab with or without prophylactic budesonide in treatment-naive and previously treated patients with advanced melanoma" (Abstract #9010, Melanoma Session) - Oral presentation beginning at 10:15 a.m. local time on Sunday, June 1, 2008. -- "Efficacy and safety of ipilimumab induction and maintenance dosing in patients with advanced melanoma who progressed on one or more prior therapies" (Abstract #9021, Melanoma Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Sunday, June 1, 2008. -- "Disease control and long-term survival in chemotherapy-naive patients with advanced melanoma treated with ipilimumab (MDX-010) with or without dacarbazine" (Abstract #9022, Melanoma Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Sunday, June 1, 2008. -- "Dose effect of ipilimumab in patients with advanced melanoma: results from a phase 2, randomized, dose-ranging study" (Abstract #9025, Melanoma Session) - Poster presentation and discussion from 2:00 p.m. to 6:00 p.m. local time on Sunday, June 1, 2008. -- "Prolonged survival in objective responders to ipilimumab therapy" (Abstract #20004) - Publication only. Ipilimumab Presentations in Prostate Cancer -- "Phase 1 trial of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration resistant prostate cancer (mCRPC)" (Abstract #5004, New Targeted Strategies for Patients with Prostate Cancer Session) - Oral presentation beginning at 11:30 a.m. local time on Monday, June 2, 2008. -- "Expanded phase 1 combination trial of GVAX immunotherapy for prostate cancer and ipilimumab in patients with metastatic hormone-refractory prostate cancer (mHRPC)" (Abstract #5146, Genitourinary Cancer Session) - Poster presentation from 8:00 a.m. to 12:00 p.m. local time on Saturday, May 31, 2008. Additional Presentations at ASCO -- "Safety and activity of MDX-1106 (ONO-4538), an anti-PD-1 monoclonal antibody, in patients with selected refractory or relapse malignancies" (Abstract #3006, Developmental Therapeutics: Immunotherapy Session) - Oral presentation beginning at 4:00 p.m. local time on Saturday, May 31, 2008. -- "Antitumor activity of anti-CTLA-4 monoclonal antibody (mAb) in combination with ixabepilone in preclinical tumor models" (Abstract #3048, Developmental Therapeutics: Immunotherapy Session) - Poster presentation from 2:00 p.m. to 6:00 p.m. local time on Sunday, June 1, 2008. -- "Effect of a fully human anti-CD70 antibody on apoptosis and dephosphorylation of MAPK proteins in chronic lymphocytic leukemia" (Abstract #3073, Developmental Therapeutics: Immunotherapy Session) - Poster presentation from 2:00 p.m. to 6:00 p.m. local time on Sunday, June 1, 2008.More information about the ASCO Annual Meeting may be found at www.asco.org.
About Medarex
Medarex is a biopharmaceutical company focused on the discovery, development and potential commercialization of fully human antibody-based therapeutics to treat life-threatening and debilitating diseases, including cancer, inflammation, autoimmune disorders and infectious diseases. Medarex applies its UltiMAb(R) technology and product development and clinical manufacturing experience to generate, support and potentially commercialize a broad range of fully human antibody product candidates for itself and its partners. More than 40 of these therapeutic product candidates derived from Medarex technology are in human clinical testing or have had INDs submitted for such trials, with seven of the most advanced product candidates currently in Phase 3 clinical trials or the subject of regulatory applications for marketing authorization. Medarex is committed to building value by developing a diverse pipeline of antibody products to address the world's unmet healthcare needs. For more information about Medarex, visit its website at www.medarex.com.
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