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Dow dips more than 500 on worries about financials- The misery worsened on Wall Street Tuesday, with stocks piling on losses late in the session and bringing the two-day decline in the Dow Jones industrials to more than 875 points amid escalating worries about credit markets and the financial sector.
Congress scolds former AIG executives over crisis- Executives at American International Group Inc. hid the full range of its risky financial products from auditors as losses mounted, according to documents released Tuesday by a congressional panel examining the chain of events that forced the government to bail out the conglomerate.
Trailing Obama, McCain hopes to gain in debate- Leading in the polls, Barack Obama hopes to cement his standing while John McCain is trying to turn his fortunes around in their second presidential debate - with economic turmoil bordering on chaos suddenly serving as the backdrop.
- Barack Obama has his William Ayers connection. Now John McCain may have an Iran-Contra connection. In the 1980s, McCain served on the advisory board to the U.S. chapter of an international group linked to ultra-right-wing death squads in Central America.
- A U.S. military officer warned Pentagon officials that an American detainee was being driven nearly insane by months of punishing isolation and sensory deprivation in a U.S. military brig, according to documents obtained by the American Civil Liberties Union and provided to The Associated Press.
- Five Massachusetts men became the first divers to reach the wreck of a 19th-century steamship that sank in one of the most destructive storms in New England history, and say they saw an array of artifacts like dishes and mugs but no human remains.
- Don't give over-the-counter cold remedies to kids under 4, drug companies said Tuesday. What sniffling little ones need, doctors said, are plenty of fluids and lots of tender, loving care.
Nick Nolte breaks window to flee from burning home- Nick Nolte has escaped a fire that burned a Malibu home to the ground. The Los Angeles County Sheriff's Department says the actor slightly cut his hand when he broke a window and fled the home shortly after 11:30 a.m. Tuesday.
- A Kansas man whose girlfriend was physically stuck to the toilet in their home wins $20,000 in the state Lottery, for the second time this year. Kory McFarren cashed in his winning $2 Bonus Crossword ticket in Great Bend Monday.
Bonds says he's enjoying life away from baseball- Barry Bonds made a rare public appearance Tuesday and said he is enjoying life away from baseball. "I'm happy now that I have more time," Bonds told the crowd at the kickoff event of the Macy's Christmas tree lighting. "I've actually enjoyed myself immensely."
BiPar Sciences Announces Clinical Data Presentations on Lead PARP Inhibitor, BSI-201, at 40th American Society of Clinical Oncology Annual Meeting
BRISBANE, Calif.
(Map)
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Findings will be presented from the first in human Phase 1 study of BSI-201, a small-molecule inhibitor of poly-ADP-ribose polymerase (PARP), as a monotherapy in subjects with advanced solid tumors. BiPar will also present a Phase 1b study evaluating BSI-201 in combination with topotecan, gemcitabine, temozolomide and carboplatin/paclitaxel in subjects with advanced solid tumors. The primary objective of these respective studies is to assess the safety profile of BSI-201 when used as a monotherapy and in combination with cytotoxic chemotherapy in subjects with measurable disease.
The schedule of poster presentations is as follows:
Title: First in Human Phase 1 Study of BSI-201, a Small Molecule
Inhibitor of Poly ADP-ribose polymerase (PARP) in Subjects with
Advanced Solid Tumors
When: Monday, June 2, 2008, 2-6 PM; Molecular Therapeutics Session
Abstract#: 3577
Title: A Phase 1B Study Evaluating BSI-201 in Combination with
Chemotherapy in Subjects with Advanced Solid Tumors
When: Monday, June 2, 2008, 2-6 PM; Molecular Therapeutics Session
Abstract #: 3579
About BiPar Sciences
BiPar Sciences is a drug development company with a therapeutic focus on exploring novel mechanisms of action in oncology. The lead development program is based on DNA repair, specifically with poly ADP-ribose polymerase (PARP) inhibitors. The lead product within that program is BSI-201, a platform drug with the potential to be a superior new treatment across a range of tumor types, both as monotherapy and in combination with chemotherapy. The company is currently testing BSI-201 in a range of Phase 2 trials in breast, brain and ovarian cancer.
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