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Why muscle sugar, D-ribose is taken by athletes & autoimmune patients to restore energy

Can D-ribose restore energy? What are cardiologists telling marathon runners, athletes, people with fibromyalgia, lyme disease, chronic fatigue syndrome, restless leg syndrome,  the generally fatigued, heart failure/heart disease patients, and the energy-depleted, frail aged about how the nutrition supplement, D-ribose can help restore energy levels depleted by drugs or stress and relieve muscle pain?

Numerous athletes such as marathon runners use L-carnitine, taurine, and CoQ10 as well as magnesium and D-ribose. For example, when a doctor who also is a marathon runner added D-ribose to his L-carnitine and CoQ10 regimen for himself,  that formula  which boosted the doctor's energy metabolism also later benefited his patients with sick hearts. The doctor added D-ribose to make a trio with L-carnitine and CoQ10.

He found that not only did the D-ribose act as if it were the missing link to more energy for healthy runners like himself, but by adding D-ribose to increase energy levels in his patients,  the energy pool in the patients with various heart diseases also increased.

D-ribose is a naturally occurring sugar that enhances energy by generating recovery of ATP levels (your body's primary energy carrying molecule). Shown to improve health and fitness in athletes, people with cardiovascular problems, and those with fibromyalgia and chronic fatigue syndrome. Also see the Chronic Fatigue Syndrome Blog's notation on D-ribose.

According to page 162 of Reverse Heart Disease Now, “There is no known adverse drug or nutritional interactions associated with D-ribose use.” If you take it with meals, there’s less of a chance your blood sugar/glucose levels will drop suddenly making you light headed. But talk to your own health care providers.

The supplement, D-ribose, found in veal also is a simple sugar molecule that your body makes in tiny amounts. But, it restores energy to frail and aged or sick hearts as well as brings back the depleted energy of marathon runners and other athletes. Perhaps D-ribose can be of help to your regimen whether you’re a young athlete or an older person losing energy fast, or have issues such as fibromyalgia. 

When D-ribose is combined with L-carnitine, CoQ10, (and magnesium citrate powder) does science have the formula for super energy? And with resveratrol added, is this an answer to slowing down the aging process? Does D-ribose help you avoid fatigue, and increase your energy without nervous stimulation?

Here are some guides to D-ribose for you to check out online. Also see the Ribo Pure site for summarized information of various studies/research related to D-ribose.

View the abstract of the study at Science Direct on D-ribose. Supplementation of d-ribose has been shown to improve cardiac metabolism. See ClinicalTrials.gov's site with the article, "The effect of oral D-ribose in 'Baby Boomers' With Fatigue. A Randomized, Double Blind Study."

The purpose and objective of the study summarized at the site notes that the objective of that research is: "An initial preliminary, open label pilot study demonstrated a positive benefit of D-ribose in 'Baby-Boomer' subjects aged 50 to 65 years old complaining of persistent fatigue."

For D-ribose and fatigue information, check out the Environmental Illness Resource site. Read Dr. Jacob Teitelbaum's Column. Jacob Teitelbaum MD is Medical Director of the Fibromyalgia and Fatigue Centers.  Dr. Teitelbaum also is senior author of the landmark studies "Effective Treatment of Chronic Fatigue Syndrome and Fibromyalgia -- a Placebo-controlled Study" & “Effective Treatment of CFS & Fibromyalgia with D-Ribose”.

D-Ribose, L-Carnitine, CoQ10, and Magnesium Citrate Powder

On one D-ribose powder supplement, that I recently bought at a health food store,  the label suggests to take D-ribose along with some magnesium, L-carnitine and CoQ10. The dose on the can label says one scoop which is 5 grams. I started out with 1/2 teaspoon of D-ribose to see if there were any effects on my energy levels. It tasted sweet, like sugar. I added it to my fruit juice with a tablespoon of magnesium citrate powder (Natural Calm), one CoQ10 softgel (ubiquinol by Life Extension, 100 mg), and a half capsule of acetyl L-carnitine.

It tasted great. On the Doctor's Best brand (can of D-ribose) the label suggests taking the D-ribose with a form of L-carnitine called L-carnitine fumarate as well as CoQ10 and magnesium.

According to the book, Reverse Heart Disease Now, the missing link to finding a food supplement that could rebuild the “metabolic energy pool” that had been depleted by heart disease turned out to be D-ribose. Sure, L-carnitine and CoQ10 helped as does magnesium citrate powder added, but only D-ribose actually boosted and rebuilt energy metabolism after disease had depleted energy. The D-ribose helped in energy recovery for both athletes and the very sick and/or elderly with failing or diseased hearts.

You should know that ATP stands for adenosine triphosphate. ATP is the "body's basic cellular fuel," according to the book, Reverse Heart Disease Now, by Stephen T. Sinatra, MD, James C Roberts, MD, with Martin Zucker, (2007). You can read on page 157, the section on D-ribose which emphasizes that with young, healthy athletes, it’s the muscle ATP pool that causes the stiffness after athletes run for long distances. But by taking D-ribose before and after running, the usual fatigue and muscle soreness was gone. In very sick heart patients with angina and heart failure that lacked the precursors of ATP, giving them CoQ10 and L-carnitine helped somewhat, but after adding D-ribose, the patients also improved.

D-ribose helps you “rebuild cellular energy and normalize diastolic cardiac function.” In studies of D-ribose, when animals were given D-ribose, energy recovery and diastolic function returned to normal after an “average of two days.”

Who should take D-ribose? First consider your age. According to the book, Reverse Heart Disease Now, the authors note on page 157 that, “We believe 20 to 25 percent of people over forty-five, men and women alike, show early signs of diastolic cardiac dysfunction (stiff heart) and are at risk of contracting heart failure later in life.”

The book emphasizes that this is “especially true in people with high blood pressure, people taking statin drugs, and in women with severe mitral valve prolapse.”

The authors note that, For these people D-ribose supplementation increases the cardiac energy reserve and helps the heart restore normal diastolic cardiac function.” 

Additionally, D-ribose helps to restore cellular energy stores. As people age, the mitochondria in our cells lose energy. Any type of stress depletes cellular energy stores. So to help your fatigue, look into the possibility of what D-ribose can do for you. If you have any metabolic stress, or are in a state of chronic energy depletion, can D-ribose offset whatever is draining your energy? (See page 158 of Reverse Heart Disease Now).

Other reasons for taking a specific amount of D-ribose include fibromyalgia, and chronic fatigue, since these issues surround problems with your ATP metabolism. D-ribose doesn’t get stored in cells. So you have to keep taking whatever maintenance dose is required for each individual.

D-ribose began to be studied in the 1940s. By 1957, scientists found that this sugar molecule played a very important metabolic reaction central to energy, for the production of genetic material, and for providing substances used by your tissues to make hormones and fatty acids. By 1973, the physiologist, Heinz-Ger Zimmer found that “energy-deprived hearts” recovered quickly if D-ribose was given prior to or just after oxygen deprivation.

By 1978, he found the same effect in muscles. But you have to keep taking D-ribose or you’ll relapse because D-ribose leaves the blood and is absorbed. D-ribose also can lower your blood sugar levels. So if you’re diabetic, tell your doctor if you’re taking insulin and D-ribose so your insulin can be adjusted.

Always talk to your health care professionals before you take any supplements to increase energy or relieve fatigue, stiffness, or pain, and other symptoms. You need to first find the cause of your individual situation.

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Sacramento Nutrition Examiner

Anne Hart is the author of more than 2,000 online articles, numerous books, and holds a graduate degree in English/creative writing. Follow Anne...

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