Here's a directory of articles based on studies on pterostilbene and resveratrol working together to mimic caloric restricton. Also studies and articles of resveratrol and/or ptersilbene working separately.
The phytochemical plant extracts are derived from grapes, blueberries, and other plants from fruit to tree bark. Interestingly, scientists began to test these plant extracts hundreds of years after the same plants had been used in India in the practice of Ayurvedic medicine.
Also see the latest study on the beneficial effects of pomegranate on prostate conditons, "Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells," National Center for Natural Product Research, Research Institute for Pharmaceutical Sciences
School of Pharmacy, The University of Mississippi, University, Mississippi 38677, Institute of Environmental Sciences, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland, J. Agric. Food Chem., 2009, 57 (22), pp 10636–10644, DOI: 10.1021/jf902716r, Publication Date (Web): October 26, 2009.
New scientific findings show the benefits of blueberries and grapes on mimicking caloric restriction and thereby creating a longer life span in the animals tested, such as mice. How will these plant extracts help humans? Scientists feel that eating a plant-based diet with blueberries and grapes, for those healthy enough to tolerate the sugar in the fruits, can have some benefits.
Beneficial Effects of Pomegranate on Prostate - Research
Also the plant, pomegranate, has been recently found to be of benefit to men with prostate conditions. The anti-prostate cancer effects of pomegranate and its extracts may be related to stopping an enzyme in the liver that processes environmental carcinogens, according to a new study.
A growing body of evidence indicates that pomegranate also protects against prostate cancer. Studies have also reported a role for pomegranate in joint health by slowing cartilage loss in arthritis.
It is the antioxidants and ellagitannin compounds like punicalagins and punicalins, which account for about half of the fruit’s antioxidant ability, that are reportedly behind the proposed health benefits.
The new study from the University of Mississippi, "Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells," reports a previously unexplored pathway through which pomegranate juice constituents may contribute to prostate cancer chemoprevention. Check out the study in the Journal of Agricultural and Food Chemistry. According to the study, pomegranate’s ellagitannin compounds may inhibit the activity of cytochrome P450 1B1, an enzyme known to be highly expressed in various human cancers, but not in normal tissues, an established target in the prevention of prostate cancer.
Scientists found that a previously unknown mechanism of pomegranate juice constituents, might contribute to prostate cancer chemoprevention. How pomegranate works is that systemically available metabolites of pomegranate juice are effective inhibitors of CYP1B1 enzyme activity/expression and could lower the incidence of prostate cancer initiation and sustenance, according to the study.
The researchers performed an in vitro experiment to test the ability of pomegranate ellagitannins and its microbial metabolites to inhibit CYP1B1. They found that the microbial metabolite urolithin A showed the greatest activity for inhibiting CYP1B1, with a 2-fold selectivity over another enzyme CYP1A1, which actually has anti-cancer activity. Inhibition of CYP1A1 is therefore not desirable.
So what does this mean in plain language? Scientists looked at how prostate cancer typically possesses long latency periods and develops in older men. Then the researchers wanted to find out whether cancer chemoprevention by dietary supplement-based intervention could work as a natural form of chemotherapy. Would pomegranate juice work for patients undergoing the conventional medical cancer therapy?
The point of the study focused on whether pomegranate juice consumption can be of considerable advantage in prostate cancer chemoprevention. Research asked such questions as will pomegranate juice help patients with a genetic predisposition toward prostate cancer as well as patients undergoing cancer therapy? The study is published online in the Journal of Agricultural and Food Chemistry, "Effects of Pomegranate Chemical Constituents/Intestinal Microbial Metabolites on CYP1B1 in 22Rv1 Prostate Cancer Cells."
In addition to studies on pomegranate, other studies focus on resveratrol and pterostilbene, other plant extracts. Below are other studies looking at how resveratrol and pterostilbene work together to mimic caloric restriction's health benefits. Caloric restriction means getting the necessary nutrition, not starving. You can peruse to see what the conclusions are or read the abstracts to get an idea of the benefits of the antioxidants in those plants and how the fruit extracts can change gene expression, hopefully for the better. Check out the studies.
Studies on Resveratrol and Pterostilbene
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Comments
Diseases are caused by one thing, which are sinful activities. Especially eating meat, bad foods, doing activities which are unhealthy like smoking etc. People are so addicted to sinful activities that they complain so much, they don't understand they have brought the results on themselves by their own actions. So before you chomp down on that burger, just think about the cow which was killed, you don't think he/she felt NO pain? You think that will go unpunished..? Actually No. You will get punished one way or another for your action. So it's best to minimize your sinful activities and live simply, animals have souls so do humans, so do plants etc.
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