When the Mercer Bears knocked off the Duke Blue Devils on March 21, it was just one of many huge upsets over the last two days as the March Madness college basketball tournament kicked off in strong style. The Round of 64 saw a number of big upsets that sent home some powerhouse teams and allowed some smaller name teams to move on to the Round of 32.
Teams like the Cincinnati Bearcats, Ohio State Buckeyes and VCU Rams all joined Duke to head home early while teams like the North Dakota State Bison, Harvard Crimson and Dayton Fliers joined Mercer in living to fight another day. The next two days of college basketball action will see if any of these teams live on to move to the Sweet 16 and a chance to be the next Cinderella.
March Madness is underway and the madness of the first upsets of the tournament are sending shockwaves through college basketball. Here is a look at the five biggest upsets of the Round of 64.