Zonisamide (Zonegran) has been evaluated as being a good choice for the treatment of partial seizures. Rx List writes that zonisamide is a sulfa drug which has anti-convulsant effects. There are potential serious side effects such as fever, sore throat, and headache with a severe blistering, peeling, and red skin rash, among others with this drug. MedPage Today reported on Sept. 22, 2013, "Zonisamide OK for New Partial Seizures."
Researchers have reported zonisamide was effective as a long-term monotherapy for the treatment of adult partial epileptic seizures and demonstrated no inferiority in comparison with carbamazepine. RX List writes that carbamazepine (Tegretol) is an anticonvulsant and specific analgesic for trigeminal neuralgia. According to Michel Baulac, MD, of Hopital Pitie-Salpetriere in Paris, France, and colleagues, after 2 years or more there was no significant difference in the number of patients who were seizure free with zonisamide versus carbamazepine therapy.
It has been noted by Baulac that a number of previous trials have compared these two drugs head-to-head and have shown no inferiority for zonisamide as a monotherapy, but none of these studies reported long-term outcomes in dealing with treatment of newly diagnosed partial epilepsy. At this time zonisamide is indicated as an adjunct treatment for focal-onset seizures with or without secondary generalization in adults in the U.S., and Europe. It is also presently indicated as a monotherapy for such seizures in adults with newly diagnosed epilepsy in Europe.