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You are what your father eats at the moment of conception: Folate deficient dads

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Mothers get all the attention. But a study led by McGill University researcher Sarah Kimmins suggests that the father's diet before conception may play an equally important role in the health of their offspring. It also raises concerns about the long-term effects of current Western diets and of food insecurity. Mice were used in the study. You can check out the full article (with illustrations), "Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes," by R. Lambrot, C.Xu, S. Saint-Phar, G. Chountalos, T. Cohen, M. Paquet, M. Suderman, M. Hallett, and S. Kimmins, published December 10, 2013 online in the journal Nature Communications.

The researchers hypothesized that the availability of one of the eight B vitamins known as folate will alter the levels of DNA methylation in sperm (spermatogenesis) with consequences for the sperm epigenome and pregnancy outcomes. Since the DNA of certain mouse models are close enough to human DNA that the outcome is theorized to be similar when it comes to nutrition deficiencies in a parent, such as a father, being passed onto the offspring at conception. What the mother eats before and near conception also affects the offspring.

The research on mice used an inbred C57BL/6 mouse model that was exposed to low dietary folate beginning in utero and throughout life. In the study, researchers showed that paternal diet alters sperm DNA methylation and is associated with negative reproductive outcomes including birth defects in offspring.

You are what your dad eats, at least in a mouse model

You are what your father eats, says a new McGill University study which suggests that a father's diet before conception plays a crucial role in the health of his offspring, according to a December 10, 2013 news release, "You are what your father eats." The research focused on vitamin B9, also called folate, which is found in a range of green leafy vegetables, cereals, fruit and meats.

It's well known that in order to prevent miscarriages and birth defects mothers need to get adequate amounts of folate in their diet. But the way that a father's diet can influence the health and development of their offspring has received almost no attention. Now research from the Kimmins group shows for the first time that the father's folate levels may be just as important to the development and health of their offspring as are those of the mother. Indeed, the study suggests that fathers should pay as much attention to their lifestyle and diet before they set out to conceive a child as mothers do.

"Despite the fact that folic acid is now added to a variety of foods, fathers who are eating high-fat, fast food diets or who are obese may not be able to use or metabolize folate in the same way as those with adequate levels of the vitamin," says Kimmins, according to a December 10, 2013 news release, You are what your father eats. "People who live in the Canadian North or in other parts of the world where there is food insecurity may also be particularly at risk for folate deficiency. And we now know that this information will be passed on from the father to the embryo with consequences that may be quite serious."

Folate deficiency and other deficiencies from food insecurity play roles as information gets passed to the embryo from the father at conception

The researchers arrived at this conclusion by working with mice, and comparing the offspring of fathers with insufficient folate in their diets with the offspring of fathers whose diets contained sufficient levels of the vitamin. They found that paternal folate deficiency was associated with an increase in birth defects of various kinds in the offspring, compared to the offspring of mice whose fathers were fed a diet with sufficient folate.

"We were very surprised to see that there was an almost 30 per cent increase in birth defects in the litters sired by fathers whose levels of folates were insufficient," says Dr. Romain Lambrot, of McGill's Dept. of Animal Science, one of the researchers who worked on the study, according to the news release. "We saw some pretty severe skeletal abnormalities that included both cranio-facial and spinal deformities."

The research from the Kimmins' group shows that there are regions of the sperm epigenome that are sensitive to life experience and particularly to diet

And that this information is in turn transferred to a so-called epigenomic map that influences development and may also influence metabolism and disease in the offspring in the long-term. (The epigenome is like a switch, which is affected by environmental cues, and is involved in many diseases including cancer and diabetes. The epigenome influences the way that genes are turned on or off, and hence how heritable information gets passed along).

Although it has been known for some time that there is a massive erasure and re-establishment that takes place in the epigenome as the sperm develops, this study now shows that along with the developmental map, the sperm also carries a memory of the father's environment and possibly even of his diet and lifestyle choices.

"Our research suggests that fathers need to think about what they put in their mouths, what they smoke and what they drink and remember they are caretakers of generations to come," says Kimmins in the news release. "If all goes as we hope, our next step will be to work with collaborators at a fertility clinic so that we can start assessing the links in men between diet, being overweight and how this information relates to the health of their children."

The research was funded by: the Natural Sciences and Research Council of Canada (NSERC), the Canadian Institute of Health Research (CIHR), Genome Québec and the Réseau Québécois en reproduction (Fonds québécois de la recherche sur la nature et les technologies). For more information, you also can check out the article in Science 2.0, "Stop Blaming Mom: Sperm Epigenome Shows You May Be What Your Father Eats." Or see the article on the original study, "Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes,"



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