Fresh from taking two of three at home against the San Diego Padres, it was on the road for the Cleveland Indians to begin a 7-game road swing against American League Central foes Chicago and Detroit.
The trip got off to a tough start with the White Sox grabbing a 7-3 win behind John Danks, who survived a 2-run first by the Indians to go six innings for the win behind a pair of home runs by Jose Abreau.
It extended the Indians losing streak to two, having lost the second game of a Wednesday afternoon double header to San Diego, 2-1.
The White Sox, 2-17 against the Indians in 2013 when Chicago lost 99 games, answered the 2-run Cleveland first with a run in the second on the first of Abrea's two home runs and two more in the third when Alexei Ramirez led off with a home run and Adam Eaton single home a run to tie the game at 3-3.
While Cleveland starter Danny Salazar was able to strike out 10 of the 11 White Sox he retired in 3.2 innings, the South Siders were able to run the Tribe pitcher in the fourth when Ramirez added a 2-run double for a 5-3 Chicago advantage.
Chicago added Abreau's second home run in the fifth and closed the scoring in the seventh when Abreau hit into a run scoring ground out.
Cleveland got on the board in the first when Jason Kipnis, a Chicago native singled and a run scored on a fielding error by Alejandro De Aza and moved to a 2-0 lead later in the inning when Ryan Raburn hit a run scoring fly ball.
The Indians other run that gave the visitors a 3-1 lead came in the third when Asdrubal Cabrera led off with a home run.
The series continues Friday with Carlos Carrasco (0-1) facing Chicago's Chris Sale (2-0). On Saturday the Indians will start Justin Masterson (0-0) against Chicago's Felipe Paulina (0-1) before closing with a Sunday clash as Corey Kluber (1-1) meets Josee Quintana (1-0)