Ranked No.6 in the world, Argentina's Del Potro will try and avoid a huge letdown against Hewitt, an unseeded Australian that's given him problems in the past.
These world-class athletes are scheduled to set the tone for the evening portion of Friday's US Open 2013 tennis action at Arthur Ashe Stadium.
ESPN-2 will be broadcasting this match live in high definition beginning at 7 p.m. EDT (4 p.m. PDT) and ESPN-3/Watch ESPN Live Stream will handle online live stream duties.
US Open 2013 tennis fans can also find an HD feed of this, and other evening matches – including Serena Williams vs. Yaroslava Shvedova – by clicking here.
It's hard to believe that Juan Martin Del Potro and Lleyton Hewitt come into tonight's match tied at 2-2 in their head-to-head series.
Despite not being seeded at Flushing Meadows this year, the No. 66 player in the world actually defeated his top-10 counterpart the last they met at the Queen’s Club in Great Britain.
On a positive note, both of Del Potro's victories come on hardcourt surface and on American soil, which could play a factor in tonight's rubber-match.
Versus Hewitt, the 2009 U.S. Open champion owns a two-set victory in 2011 (San Jose, Calif.) and beat him by going the distance in 2009 in the nation's capital.
According to US Open 2013 tennis odds makers, Juan Martin Del Potro is listed as a huge [-800] favorite to move passed Lleyton Hewitt [+500].
The winner of this match moves on to the US Open 2013 tennis third round to face the victor of the Evgeny Donskoy vs. Peter Gojowczyk contest. How will this Juan Martin Del Potro vs Lleyton Hewitt live stream match play out?
Can the Argentine jump ahead in their head-to-head series or is the two-time Grand Slam champ poised for his second career Flushing Meadows title?