It will be the first US Men's National Team back in the United States since the 2014 World Cup and will be the first time the team has come to Texas since January 2013.
The match pits two of the top 20 sides in the FIFA rankings against each-other and will be the biggest match in San Antonio in some time.
The Mexican National Team played Korea Republic in the same venue in January, and drew 54,000 people but US Soccer, putting a bigger opponent against the USA will be hoping to break that crowd, a San Antonio soccer record, with 59,066 standing as the biggest USA Men's Team home crowd for 2014, another mark San Antonio will be looking to beat.
The match will be a big chance to commence the next World Cup cycle, while also potentially acting as a farewell game for US veterans who may see the first home friendly as a chance to say farewell to US National Team play.
It's perhaps a more important match for Colombia, as they have a major tournament in 2015, with the traditional Copa America being pushed forward one year, in order to accommodate the special centenario edition in the United States in 2016.
San Antonio fans will be treated to some stars of soccer with the match coming to the Alamodome with US Stars Clint Dempsey and Tim Howard while also welcoming the winner of the Silver Ball, and many in the media's star of the World Cup, James Rodriguez.
Rodriguez won the Golden Boot and scored what was popularly voted the goal of the World Cup by fans on FIFA's website.
The match presents another opportunity to impress the soccer decision makers, as the city could continue to push for an MLS side in the city.