The Black Bears are coming off a 23-6 victory over Norfolk State.
Marcus Wasilewski threw for 209 yards and one touchdown in the season opener.
Joseph Zedric scored on an 85 yard touchdown reception for the Black Bears.
Maine (1-0) allowed only 80 yards rushing on 34 carries against Norfolk State.
The Maine and Massachusetts rivalry started in 1909. The last time they faced each other was in 2011 at Orono. The Black Bears won that game 32-21.
The Minutemen went 1-11 last season in their first as a Football Bowl Subdivision team.
You can watch the broadcast live at 2 p.m. on ESPN3.com or the WatchESPN app for mobile devices.