Silva, 38, suffered an unfortunate leg injury, as his leg snapped near the ankle after Weidman blocked a low kick.
"It's a sh*tty way to see him go out," UFC President Dana White said at the UFC 168 post-fight press conference, referring to Silva. "But it's part of the game."
Weidman is expected to move on to fight perennial title contender Vitor Belfort, an MMA legend. No word yet on when that fight will be.
As for Silva, he was rushed to the hospital following his fight with Weidman.
He didn't officially announce his retirement, but it's highly unlikely he'll be willing to go through the rehab necessary to make a full recovery from his injury.
At age 38, UFC 168 may have been the last time fight fans will have gotten the chance to see him in action.
In the UFC 168 co-main, Rousey retained her UFC bantamweight belt with a third-round finish of Miesha Tate.
Despite a crisp performance, Rousey was roundly booed by the crowd on hand because she refused to shake Tate's hand once the fight was over.
“In judo, I didn't know what a cheer was, cheers are what's new,” Rousey said. “I took the name ‘Rowdy’ after ‘Rowdy’ Roddy Piper because he was such a great showman. I wanted to put on a good show.
“I respect Miesha very much as a competitor but I can't respect a fighter who did what she did and I cannot shake her hand because of it."
Rousey is pleased she had the opportunity to show off more of her skillset to the UFC faithful.
“Going more than one round was a good experience,” Rousey said. “In judo, I had to go five founds. The experience is good, going longer than one round. I needed that experience in the octagon, and as my mom said, better to get it in a win than in a loss.”
Here's a look at the full UFC 168 results:
- Chris Weidman def. Anderson Silva by TKO (leg injury). Round 2, 1:16 - for middleweight title
- Ronda Rousey def. Miesha Tate by submission (armbar). Round 3, 0:58 - for women’s bantamweight title
- Travis Browne def. Josh Barnett by knockout (elbows). Round 1, 1:00
- Jim Miller def. Fabricio Camoes by submission (armbar). Round 1, 3:42
- Dustin Poirier def. Diego Brandao by TKO (punches). Round 1, 4:54
- Uriah Hall def. Chris Leben by TKO (doctor’s stoppage). Round 1, 5:00
- Michael Johnson def. Gleison Tibau by knockout (punch). Round 2, 1:32
- Dennis Siver def. Manny Gamburyan by unanimous decision (29-28 x3)
- John Howard def. Siyar Bahadurzada by unanimous decision (30-27 x3)
- William Macario def. Bobby Voelker by unanimous decision (30-27 x3)
- Robbie Peralta def. Estevan Payan by knockout (punches). Round 3, 0:12