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Tendency toward having very dry skin, dermatitis, asthma, and food allergies?

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In human evolution, changes in skin's barrier set Northern Europeans apart, says a new study from the University of California - San Francisco (UCSF). This research questions role of skin pigment in enabling survival at higher latitudes. The popular idea that Northern Europeans developed light skin to absorb more UV light so they could make more vitamin D – vital for healthy bones and immune function – is questioned by UC San Francisco researchers in a new study published online in the journal Evolutionary Biology. Evidence for a south to north gradient in the prevalence of melanin mutations is weaker than for this alternative explanation explored by Elias and colleagues.

Ramping up the skin's capacity to capture UV light to make vitamin D is indeed important, according to a team led by Peter Elias, MD, a UCSF professor of dermatology. However, Elias and colleagues concluded in their study that changes in the skin's function as a barrier to the elements made a greater contribution than alterations in skin pigment in the ability of Northern Europeans to make vitamin D.

For the Evolutionary Biology study, labeled a “synthesis paper” by the journal, Elias and co-author Jacob P. Thyssen, MD, a professor at the University of Copenhagen, mapped the mutation data and measured the correlations with blood levels of vitamin D. Labs throughout the world identified the mutations. Daniel Bikle, MD, PhD, a UCSF professor of medicine, provided expertise on vitamin D metabolism. The study researched blood levels of vitamin D worldwide to identify mutations. A synthesis paper contains the result of an integration of what individuals researched, heard, or read, and the research team's ability to use this learning to develop and support a key thesis or argument.

Elias' team concluded that genetic mutations compromising the skin's ability to serve as a barrier allowed fair-skinned Northern Europeans to populate latitudes where too little ultraviolet B (UVB) light for vitamin D production penetrates the atmosphere

Among scientists studying human evolution, it has been almost universally assumed that the need to make more vitamin D at Northern latitudes drove genetic mutations that reduce production of the pigment melanin, the main determinant of skin tone, according to Elias. "At the higher latitudes of Great Britain, Scandinavia and the Baltic States, as well as Northern Germany and France, very little UVB light reaches the Earth, and it's the key wavelength required by the skin for vitamin D generation," Elias said, according to the June 30, 2014 news release, "In human evolution, changes in skin's barrier set Northern Europeans apart."

"While is seems logical that the loss of the pigment melanin would serve as a compensatory mechanism, allowing for more irradiation of the skin surface and therefore more vitamin D production, this hypothesis is flawed for many reasons," he continued. "For example, recent studies show that dark-skinned humans make vitamin D after sun exposure as efficiently as lightly-pigmented humans, and osteoporosis – which can be a sign of vitamin D deficiency – is less common, rather than more common, in darkly-pigmented humans." Furthermore, evidence for a south to north gradient in the prevalence of melanin mutations is weaker than for this alternative explanation explored by Elias and colleagues.

In earlier research, Elias began studying the role of skin as a barrier to water loss. He recently has focused on a specific skin-barrier protein called filaggrin, which is broken down into a molecule called urocanic acid – the most potent absorber of UVB light in the skin, according to Elias. "It's certainly more important than melanin in lightly-pigmented skin," he said, according to the news release.

In their new study, the researchers identified a strikingly higher prevalence of inborn mutations in the filaggrin gene among Northern European populations.

Up to 10 percent of normal individuals carried mutations in the filaggrin gene in these northern nations, in contrast to much lower mutation rates in southern European, Asian and African populations. Moreover, higher filaggrin mutation rates, which result in a loss of urocanic acid, correlated with higher vitamin D levels in the blood. Latitude-dependent variations in melanin genes are not similarly associated with vitamin D levels, according to Elias. This evidence suggests that changes in the skin barrier played a role in Northern European's evolutionary adaptation to Northern latitudes, the study concluded.

Yet, there was an evolutionary tradeoff for these barrier-weakening filaggrin mutations, Elias said. Mutation bearers have a tendency for very dry skin, and are vulnerable to atopic dermatitis, asthma and food allergies. But these diseases have appeared only recently, and did not become a problem until humans began to live in densely populated urban environments, Elias said, according to the news release.

Tendency toward having very dry skin, dermatitis, asthma, and food allergies

The Elias lab has shown that pigmented skin provides a better skin barrier, which he says was critically important for protection against dehydration and infections among ancestral humans living in sub-Saharan Africa. But the need for pigment to provide this extra protection waned as modern human populations migrated northward during the past 60,000 years or so, Elias said, according to the news release, while the need to absorb UVB light became greater, particularly for those humans who migrated to the far North behind retreating glaciers less than 10,000 years ago.

The data from the new study do not explain why Northern Europeans lost melanin. If the need to make more vitamin D did not drive pigment loss, what did? Elias speculates that, "Once human populations migrated northward, away from the tropical onslaught of UVB, pigment was gradually lost in service of metabolic conservation. The body will not waste precious energy and proteins to make proteins that it no longer needs."

You also may be interested in looking at an older study by different researchers published July 9, 2013, "DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes." Funders of the research include the San Francisco Veterans Affairs Medical Center, the Department of Defense, the National Institutes of Health, and a Lundbeck Foundation grant.

UCSF is the nation's leading university exclusively focused on health. Now celebrating the 150th anniversary of its founding as a medical college, UCSF is dedicated to transforming health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with world-renowned programs in the biological sciences, a preeminent biomedical research enterprise and two top-tier hospitals, UCSF Medical Center and UCSF Benioff Children's Hospital San Francisco. You also can check out the UCSF website.

Noteworthy are the abstracts of these other studies, "Different level of population differentiation among human genes." Check out, "The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents." Or noteworthy is another study, "Is sugar intake linked with breast cancer risk?" There's also of interest the study, "Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia." Or see, "DHCR7 mutations linked to higher vitamin D status allowed early human migration to Northern latitudes." You also may wish to read the blog article, " You can transform your genetic ancestry data into health information, but your results may vary."

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