The adverse health effects associated with obesity can be so serious many people consider drugs to help them lose weight and to stay thin. It has been written by Medline Plus that Orlistat is used with an individualized low-calorie, low-fat diet and exercise program to help people lose weight. MedPage Today reported on Sept. 19, 2013, "Orlistat Helps Trim Waistlines."
A meta-analysis has found that treatment of overweight and obese people with orlistat (Xenical, Alli) was associated with decreased waist circumference to a greater degree than either placebo or standard care. In contrast to this finding, the analysis didn't show any significant effects for lorcaserin (Belviq) on waist circumference. Waist circumference has been shown to reflect higher-risk abdominal fat, and has been linked with cardiovascular disease and mortality.
Orlistat has been approved for clinical use by both the FDA and the European Medicines Agency (EMA). The mode of action of orlistat is to block the digestion of fat. The effects of orlistat have been found to be smaller at 12 months than at 6 months, therefore suggesting it may not be as effective in the long term. There may be some troubling side effects with this s drug which should be discussed with your pharmacist or physician.