Danny Green scored five straight points that gave the Spurs a 56-51 halftime lead over the Clippers.
The Clippers played with a lack of energy that was displayed during the entire game, while the Spurs continued to play through their fatigue and remained focused.
"I'm just really tired, I didn't have my legs tonight," said Blake Griffin. "The next two days off will be good for us, we can really use the rest."
Marco Belinelli showed why he is the three point champion, when he knocked down a three pointer with less than three minutes left in the third quarter. The Spurs increased their lead over the Clippers 73-69. In the last minute of the same quarter Tim Duncan picked up his fourth foul.
Mills scored 16 of his 25 points in the fourth quarter, as the Spurs built a 93-86 lead with just under eight minutes remaining.
Duncan picked up his fifth foul, and continued to be force making a short basket, along with Mills connected on a long three pointer sealed the game for the Spurs.
I think my fourth and fifth ones were not very smart. I didn't realize where I was, foul-wise, and I kind of got myself in trouble there," Duncan said. "But they weren't able to take advantage of it, luckily, and we all played through it."
Blake Griffin finished with 25 points and 13 rebounds, Jamal Crawford scored 25 points, and DeAndre Jordan finished with 7 points and 18 rebounds.
"We've got a lot of work to do to get where the Spurs are and accomplish what they've accomplished," Griffin said. "They kind of have the model of the NBA and how you want to run things. Guys can be sitting out with injuries, and it still doesn't matter."
Chris Paul struggled the entire game and finished 1/10 from the field, scored 11 points and nine assist.
"He just looked tired out there tonight. It happens," said coach Doc Rivers about Paul's performance.
Tim Duncan scored 19 points with 13 rebounds in the victory on Tuesday night.
"Down a couple of guys, not being able to practice yesterday, and to be able to come in here and put together a 48-minute performance like this was great for us," said Duncan.
Parker being out indefinitely due to a multitude of injuries, Tiago Splitter was also out with a bruised right shin, and Kawhi Leonard was sidelined with a broken bone in his hand.
The Clippers will face a tough road trip that begins in Memphis on Friday against the Grizzles.