The Billie Jean King USTA National Tennis Center in Flushing, N.Y., will be the site for this late afternoon/early evening fourth-round showdown.
The ladies are scheduled to take Arthur Ashe Stadium around 3:30 p.m. EST (12:30 p.m. PST) following the conclusion of the men's singles match between Andy Murray and Florian Mayer.
CBS-Sports will handle broadcasting duties for both matches, as their TV time coverage gets underway at 1 p.m. EST (10 a.m. PST).
For tennis fans that prefer to watch a feed Sloane Stephens vs. Serena Williams 2013 U.S. Open live streaming match, click here.
The Stephens-Williams rivalry has quickly become a fan favorite, despite the fact that these players have only met in two prior occasions.
With their head-to-head series tied at one win apiece, tonight's rubber-match promises to be a dandy, especially considering there's no love lost between the two.
The 20-year-old Stephens entered Williams' radar when she stunned the 16-time Grand Slam champ in the quarter-finals of 2013 Australian Open (3-6, 7-5, 6-4).
After admitting she was a longtime Serena fan, adding she even had a poster of the world's No.1 on her wall, the 15th-seeded American decided to throw a jab.
"I think I'll put up a poster of myself now," Stephens said following her three-set victory.
Williams would make her feelings clear in the ensuing months, as the Fed Cup teammates' relationship would never be the same after what took place Down Under.
"She's not said one word to me, not spoken to me, not said hi, not looked my way, not been in the same room with me since I played her in Australia," she added. "And that should tell everyone something, how she went from saying all these nice things about me to unfollowing me on Twitter."
Who will win the rubber-match? Don't miss a minute of the Sloane Stephens vs Serena Williams 2013 U.S. Open live streaming match, which has a tentative TV time of 3:30 p.m. (EST) on Sunday at Arthur Ashe.