Skip to main content
  1. News
  2. Science & Space

Scientists report first sound-sensing hair cell regeneration

See also

The first method to regenerate sound-sensing hair cells and thus restore hearing in animals was reported by Dr. Albert Edge of Harvard Medical School and Massachusetts Eye and Ear Infirmary and colleagues in the Feb. 20, 2014, edition of the journal Stem Cell Reports.

The researchers found that blocking the major cell signaling pathway (Notch) in the ear produced an excitation of neighboring cells. The neighboring cells produced hair cells. Hair cells are necessary for hearing. The study was conducted in mice.

The only cells that were induced to produce hair cells were those cells that express a protein called Lgr5 (leucine-rich repeat-containing G-protein coupled receptor 5). More cells containing Lgr5 can be induced to produce hair cells by the inhibition of the notch protein.

The majority of hearing loss in humans is the result of hair cell loss due to noise damage.

This is the first research that documents that hair cells in the ear that are responsible for initiating the vibrations that result in hearing can be replaced both naturally at low levels and at much higher rates through chemical manipulation.

The researchers plan further tests with humans to develop a method of hearing restoration that is simple and makes use of naturally occurring chemistry in the ear.

Advertisement

News

  • Al Qaeda video surfaces
    A video of an Al Qaeda meeting surfaces, concealed identities are raising suspicions
    Video
    Watch Video
  • Boston Marathon
    Boston cops shut down Boylston street after finding suspicious, unattended backpacks
    Top News
  • Death penalty for hate crime?
    Actions by the anti-Semitic gunman are being condemned by the unlikeliest of groups
    Crime News
  • New York gun control
    As many as one million New Yorkers are ready to disregard the state's new gun laws
    Headlines
  • Korean ferry capsizes
    Hundreds of passengers are missing after a ferry sinks off the South Korean coast
    World News
  • NYPD ends surveillance on Muslims
    The NYPD will end surveillance programs against Muslims in their own communities
    Video
    Watch Video

Related Videos:

  • Purchase Your Pair of Google Glass Today
    <div class="video-info" data-id="518193403" data-param-name="playList" data-provider="5min" data-url="http://pshared.5min.com/Scripts/PlayerSeed.js?sid=1304&width=480&height=401&playList=518193403&autoStart=true"></div>
  • Camp Invention
    <iframe width="560" height="315" src="//www.youtube.com/embed/p3XUiL6YDcY?VQ=HD720&amp;autoplay=1"></iframe>
  • Stanford scientists Matthew Kanan and Christina Li have created an oxide-derived copper catalyst that converts carbon monoxide to ethanol.
    <div class="video-info" data-id="518178005" data-param-name="playList" data-provider="5min" data-url="http://pshared.5min.com/Scripts/PlayerSeed.js?sid=1304&width=480&height=401&playList=518178005&autoStart=true"></div>

User login

Log in
Sign in with your email and password. Or reset your password.
Write for us
Interested in becoming an Examiner and sharing your experience and passion? We're always looking for quality writers. Find out more about Examiner.com and apply today!