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Rob Lowe talks 'Grey's Anatomy' mistake and squeezing the most out of life

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Emmy and Golden Globe nominated actor Rob Lowe stopped by “Good Morning America” on April 8 to promote his new memoir, “Love Life,” which was just released today by Simon & Schuster.

Lowe chatted with GMA co-host George Stephanopoulos about his most recent foray into writing which using stories and observations in his life to touch on universal truths many readers can relate to.

Stephanopoulos couldn’t resist mentioning one of Lowe’s potentially biggest career missteps in turning down the role of Dr. Derek Shepherd on Shonda Rhimes’ hit medical drama, “Grey’s Anatomy” which eventually went to the series lead actor, Patrick Dempsey.

Lowe said, “I tell that story because I’m talking about how all actors and all people come to places in their lives where they have a choice. Did they make the right choice? Did they make the wrong choice? What goes into making those choices? So, what’s in that story is the thought process I had when I chose a different show over that and it’s called “Wish Sandwich” and it’s one of my favorite chapters.

Lowe has endured some definite flops in an overall stellar career, including the short-lived 2003 NBC drama “The Lyon’s Den,” which he also executive produced and “Dr. Vegas” for CBS. It seemed hard for him to achieve series success after the incredible run he had from 1999-2003 playing Sam Seaborn on NBC’s heavily decorated Emmy Award-winning series “The West Wing.”

However, Rob went on to garner more critical acclaim as Calista Flockhart’s love interest, Senator Robert McCallister on ABC’s hit family drama “Brothers and Sisters,” before moving on in 2010 to the role of Chris Traeger on NBC’s Emmy and Golden Globe nominated sitcom “Parks and Recreation.”

The handsome and charismatic actor reached a notable age in turning 50 this year on March 17. This monumental milestone was also accompanied by another life-changing personal event, with his eldest son Matthew leaving for college.

Lowe said, “I knew it would be a big change for my son and for me and for the whole rest of the family. But I was not prepared for how emotional it was for me. My wife, Sheryl, was like a rock; probably because she saw me being –“

Stephanopoulos interjected, asking, “Why do you think it hit you so hard?”

Lowe said, “That’s one of the reasons why I wanted to write the chapter, because I thought by writing about it, I could come to terms with it. I think it has to do with a lot of things. I think it has to do with transition. I think it has to do with mortality. I think it has to do with wanting to keep your kids the way they are forever and then the joy of turning them over to the world. It’s great because everybody goes through it. But yet, it feels so unbelievably unique.”

Stephanopoulos noted that the resounding principle that Lowe has done “a terrific job of squeezing the most out of every stage of your life.”

Lowe took this as a huge compliment, noting that “at its core, what the book is about for everybody. It doesn’t matter what you do, or where you live or what your job is. Everybody is the architect of their own life. The whole point of it is living life to the fullest.”

The engaging memoir is a follow up to Lowe’s 2011 hit autobiography, “Stories I Only Tell My Friends.” It is available in hardback and electronic format, with the hardback being 272 pages.

Check out the “Love Life” table of contents and sample pages on


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