Hyji Thomas went close to getting a rare triple-double as he managed 11 points, 11 rebounds and nine assists in a dominant performance.
All of Thomas' points came in the second half missing just three of his attempts while Bjorn Sherman and Jordan Sims both hit 16 points, a season high for each.
The domination on the scoreboard was reflected throughout the statistics, notably on rebounds which UTSA lead 54-27.
The Roadrunners started well, draining six of their first seven attempts as they worked out to a 15-7 lead that they would easily hold for the remainder of the game.
With 12:32 remaining in the half Jordan Sims netted a 3-pointer to take their lead out to ten points and it just continued to balloon from there as the Roadrunners scored from all over the court.
The half concluded for UTSA with a 7-1 run which saw the Roadrunners take a 36-18 lead with 2:19 to play in the half.
There was an attempted come back from Huston-Tillotson but it did little with UTSA still holding a 37-22 lead at the break.
A dunk gave UTSA a nice start to the half before a three point play pushed UTSA's lead out to 47-25 with over 15 minutes to play.
From there the Roadrunners just closed out the game with ease as they never saw their lead go lower than 17 before UTSA took their biggest lead right near the end at 90-60.
The result is a big morale boost for the Roadrunners who have gotten off to an awful start but this big win will hopefully spur them on to bigger things.