Albuquerque (24-30) lost three of four at Sacramento (34-21). The Isotopes trailed the River Cats 5-0 and 7-2 but could never overtake them.
In the ninth, Josh Judy (2-1) gave up a leadoff single to Andy Parrino. After a double by Stephen Vogt, Nate Freiman lined a single to right, scoring Parrino with the winning run.
Back in the fifth, Albuquerque trailed by five runs, only to see Jeremy Hazelbaker hit a three-run homer and Clint Robinson hit a two-run shot. Hazelbaker's blast was his first as an Isotope.
Starter Sam Demel gave up seven runs on eight hits and two walks in 3.2 innings. Steve Smith and Paco Rodriguez followed with 4.1 scoreless innings to keep the game tied.
Jeremy McBryde (3-1) picked up the victory with a scoreless ninth. Former Isotope Nick Buss went 3-for-4 with a double, a home run and four RBI.
Albuquerque will return home Saturday night to face Salt Lake at 7:05 p.m. The Isotopes will send right-hander Carlos Frias (2-3, 5.77 ERA) to the mound against the Bees' Justin Thomas (2-5, 6.29).