Synthetic activation of the gene sirtuin1 produces longer life, healthy aging, and a host of health benefits according a report by Dr. Rafael de Cabo of the National Institute on Aging at the National Institutes of Health published in the journal Cell Reports on Feb. 27, 2014.
The researchers fed one group of mice 100 milligrams per kilogram of body weight of SIRT1720 daily beginning at six months of age. SIRT1720 activates the function of the sirtuin1 gene at extremely accelerated rates. A second group of mice received no supplement in their diet.
The mice that consumed SIRT1720 demonstrated an extended life span of 8.8 percent, lower body fat, a lower body weight, improved muscle function, improved motor coordination, a reduction in total cholesterol levels, a lowering of LDL cholesterol levels, a lower potential to develop diabetes, and a reduction in chronic inflammation compared to the mice that consumed no SIRT1720.
The synthetic initiation of the sirtuin1 gene by SIRT1720 could reduce the rates of heart disease, diabetes, and many age-related diseases in an increasingly older population in the United States.
Dr. de Cabo says "It illustrates that we can develop molecules that ameliorate the burden of metabolic and chronic diseases associated with aging."