Lefty Chris Reed has not looked good in his last two starts at Isotopes Park. He did not look any better on the road Sunday night.
The RedHawks (71-66) took control in the second inning. Matt Duffy hit a leadoff double and Domingo Santana followed with an RBI single.
L.J. Hoes then drew a one-out walk to set up Carlos Perez, who lined a two-run double to center field to make it 3-0. Reed would go on to allow runs in the fourth and fifth innings as well.
Albuquerque (59-76) scored its only runs in the fifth inning. Trayvon Robinson hit a two-run triple and Joc Pederson followed with an RBI single.
The Isotopes are one loss away from tying the 2004 club for the most in a single season. They have already guaranteed that they cannot match their lowest win total (67, also from 2004) thanks to two games canceled by rain this year.
Richard Rodriguez (2-0), Pat Urckfitz and Jason Stoffel combined for 4.1 scoreless innings of relief for Oklahoma City. Stoffel earned his 11th save.
The Isotopes and RedHawks will continue their series Monday at 6:05 p.m. Right-hander Matt Magill (7-5, 4.98 ERA) will start for Albuquerque against Oklahoma City right-hander Asher Wojciechowski (3-4, 4.09).