Those with Lyme disease suffer from a severe form of depression because Lyme destroys the serotonin receptors in the brain. However, many others suffer from severe, crushing depression as well; so this information may prove useful for any depression sufferer. Alright, let’s get to the alarming facts right off the bat –although quite frankly, they are all pretty alarming. With more than 350 million people suffering from depression across the globe, it is a no brainer that antidepressants are the number one drug prescribed by doctors .
“The truth is that even experts aren’t really sure how antidepressants work. There’s just a whole lot we don’t know about how the brain functions. ”
Perhaps that last sentence should be, “There’s just a whole lot we don’t know about how the antidepressants we prescribe so freely function.” How does anyone develop a pill without knowing how it will work in the brain? Do they just take their best guess and throw chemicals together, hoping it works when they use humans as guinea pigs? Admitting you do not know everything is a highly respectable act, except when you still continue to alter the brains of human beings without knowing the consequences after doing so.
The answer to how psychedelic mushrooms containing Psilocybin function in the brain to treat depression is far more simple and clear cut. There is an actual answer, as opposed to a slew of “educated” guesses. In depressed individuals, there is over activity in the anterior cingulate cortex. Psilocybin possesses the power to switch off the over activity in this part of the brain.  Then, rather than increasing levels of serotonin in the brain, Psilocybin binds to serotonin receptors and mimics them, causing the brain to function as if it has more serotonin without actually altering the levels themselves. This last part is a crucial defining fact in deciding between the safety of antidepressants and psychedelic mushrooms in treating depression.
A serious and potentially fatal syndrome called ‘Serotonin Syndrome,’ which occurs when serotonin levels become too high, can occur from taking antidepressants. Many render this rare, but considering antidepressants increase the chemical serotonin in the brain, developing serotonin syndrome is a possibility to consider; as ‘rare’ is not a synonym for ‘nonexistent.’ Psychedelic mushrooms, on the other hand, do not put you at risk of developing serotonin syndrome because Psilocybin merely mimics serotonin receptors rather than actually increasing serotonin levels.
While psychedelic mushrooms take approximately three hours to work, most antidepressants take two to four weeks to start working, because increasing levels of neurotransmitters is a gradual process . Something about the fact that chemicals are unnaturally building up in your brain is a cause for slight concern, much less the fact that doctors and chemists are unsure of how exactly these antidepressants work. Messing with chemicals and neurotransmitters in the brain without having a firm grip of how you are doing so does not seem rational, logical, or humane. However, most of us are conditioned from birth to trust our doctors and pharmaceutical companies.
There are not any noted side effects of psychedelic mushrooms, other than the ones you experience while under the influence of them. The laundry list of potential side effects from taking antidepressants includes:
Immune system problems: SSRI antidepressants cause serotonin to remain in the nerve junctions longer, interfering with immune cell signaling and T cell growth.
Still births are twice as likely if the mother is on antidepressants
There is a 40% higher risk of birth defects, such as cleft palate, if the mother is on antidepressants while pregnant.
45% higher risk of having a stroke, as antidepressants affect the blood clotting process
Sudden cardiac death: your risk of sudden death doubles while on antidepressants.
Rapid heart beats
Headaches and migraines
Insomnia for some, chronic fatigue for others
Loss of appetite
Inability to orgasm
Low sex drive
And let’s not forget, serotonin syndrome
Close to a million lives are lost yearly due to suicide from depression, which comes out to three thousand suicide deaths a day . Unfortunately, that alarming fact alone cannot wake the medical world up to see what they are doing is incorrect, and not working. From the outside looking in, one must admit it appears as if they are selfishly denying people the right to proper, harmless treatments such as Psilocybin containing mushrooms. Why would anyone do such a thing? That is a question we must continually ask ourselves in this day and age, as sincere concern for the public appears to be obsolete in various situations.
Death rates from antidepressants range around forty-thousand annually. Suicidal thoughts and feelings, as well as violent behavior are ironically common side effects of antidepressants. Even more ironic, is the fact that your risk for suicide is twice as high when taking SSRI antidepressants. Death rates from antidepressants are also 32% higher in females .
No valid evidence exists to confirm any deaths from magic mushrooms; and deaths from acute poisoning from such mushrooms has not been recorded in medical literature. However, it is imperative to remember there are actually poisonous mushrooms that are entirely different from the typical Psilocybin psychedelic mushrooms referred to in this text. In fact, blindly ingesting the wrong mushroom can prove to be fatal.
All in all, from chemistry explained, to side effects to no side effects, to forty thousand deaths a year to zero deaths a year, it is clear that psychedelic mushrooms can be a more appropriate, safe approach for treating depression. One can only hope for a world where one day we can go to a psychedelic psychologist, take psychedelic mushrooms in a controlled setting, and come out three hours later relieved of depression. Can you imagine? No more monthly doctor fees. No more monthly prescription fees. No more taking a pill a day. No more withdrawals. No more side effects.
Andrews, Paul (2012). Things Your Doctor Should Tell You About Antidepressants. April 15, 2013 from Mad in America: Science, Psychiatry, and Community. http://www.madinamerica.com/2012/09/things-your-doctor-should-tell-you-a...
Marcus, Marina, Yasamy, Taghi, Van Ommeren, Mark, Chisholm, Dan, and Sheknar Savena WHO Department of Mental Health and Substance Abuse. Depression: A Global Concern. Paper published by the World Health Organization
Mercola (2011). They Cause 40,000 Deaths a Year, But They’re Handed Out Like Candy. Retrieved April 15, 2013.http://www.articles.mercola.com/sites/articles/archive/2011/05/03/tips-t...
Freeman, Shanna (2011-2013). How Magic Mushrooms work. Retrieved April 15, 2013. http://www.science/how stuffworks.com/magix-mushroom1.htm
Retrieved April 15, 2013 http://webmd.com/depression/how-different-antidepressants-work
Retrieved April 15 2013 http://nhs.uk/conditions/antidepressant-drugs/pages/how-do-they-work.aspx
Video: Psilocybin and the Psychedelic State –Dr.Robin Carhart Harris