Recently, Bethesda Softworks yanked Prey 2 off its upcoming list of Summer 2013 titles when it became apparent the game would not be ready as expected, but a newly discovered countdown site hints at a reveal related to Prey 2. The website in question, AlienNoire.com, doesn't mention the game itself, but NeoGAF users snagged an image of the now-changed source code for the site counting down to 1 March, which included keyword entries for the game title and Human Head Studios, the game's developer.
A quick WHOIS lookup reveals that the domain owner's name is listed as "The Collective", with an adress in Tahlequa, OK. Tahlequa is the city where Tommy, the protagonist of Prey, is from, and where the capital of the Cherokee nation was initially founded. It is also worth noting here that Tommy is also a Cherokee. Add that to the newly edited source code to the site that includes a hidden reference, with a message that reads "Tommy needs your help."
Please keep in mind that it is entirely possible that this could very well be the very creative work of a fan. We'll just have to sit and wait, until either 1 March arrives or Bethesda offers some commentary regarding the website.