Flight 289 took off for Shanghai, China at around 11:15 a.m. The jet hit the birds a few minutes later. The species or number of birds was not confirmed. However, they have been Canada geese.
According to NBC Chicago, fire and rescue teams were dispatched to O'Hare immediately after the incident.
Damage to the plane was minimal, American Airlines spokesmen said. None of 237 passenger or 15-member were injured.
The incident was the second in a month involving a Chicago flight. Three weeks ago, a jet that took off from Chicago made an emergency landing in North Carolina after a bird flew into one of its engines.
More than 400 similar incidents have been reported since early 2012. Reports show that birds vs. plane mishaps have been on the rise in Chicago for the past two decades.
While most planes do not sustain significant damage when hitting birds, more than 50 have been destroyed since 1990 because of wildlife encounters.
As of this report, the Boeing 777-200 was still being inspected at O'Hare. When it is expected to re-board isn't known.