The Nets dug themselves a 21-point hole that proved too deep to overcome. Although the Nets came within a possession of knotting the game, the Pistons prevailed. Kyle Singler drained two free-throws with 10 seconds remaining to seal the game.
The loss dropped the Nets to 8-15 and snapped a three-game winning streak.
"The guys fought for 48 minutes and I told them that after the game," Nets head coach Jason Kidd said. "I was proud of them for fighting."
The Pistons took advantage of a Nets team playing without starting center Brook Lopez, pounding Brooklyn in the paint, 60-38. Lopez suffered a sprained ankle during the Nets' win Thursday night against the Los Angeles Clippers.
Although Lopez said he wanted to play following the win over the Clippers, he conceded that the ultimate decision rested with the team's medical staff.
Frontcourt towers Andre Drummond and Greg Monroe notched 22 points apiece while the duo grabbed 13 and 11 rebounds, respectively.
"We gave up way too many points in the paint," Kidd added. "Going up against better team's we'll have to address that."
The Nets responded with no answers as they started Reggie Evans in Lopez's place, but Evans only played 10 minutes. Kevin Garnett failed to make an impact too, scoring just four points in 18 minutes.
Mirza Teletovic emerged as a silver lining in the loss. Teletovic went 5-for-6 from behind the arc and scored 17 points in 24 minutes off the bench.
In addition to Lopez, the Nets continued to play without Jason Terry and Andrei Kirilenko. Both appear closer to returning but still might miss at least one more week before returning to action.