UPDATE: Check out the Comments section for a note from "Amazing Spider-Man" writer Dan Slott.
Today at the Chicago Comic & Entertainment Expo, Marvel Comics announced their Spider-Man tie-in to their currently running "Original Sin" event. "Original Sin" is the story of Uatu the Watcher's murder and the release of all his collected knowledge as a result. Throughout the course of the event, many dark secrets from Marvel's past are revealed about its heroes.
All of Marvel's major titles tie-in to the mega event, with each book revealing some previously unknown "sin" from the hero's past. Spider-Man is no different. As it turns out, there was someone else who was bitten by the very same radioactive spider as Peter all those years ago. That character is named Silk and from the look of that teaser image, Parker is responsible for what happened to her.
There is only one problem with that. Peter Parker already has an "original sin." And to suggest there is any deeper, darker sin from Spider-Man's early days undermines the character at its very core. When Parker was first bitten by that radioactive spider and granted extraordinary abilities, he did not immediately set out to become a super-hero. He used those abilities to achieve personal fame and fortune. It was only after his original sin of arrogantly allowing a burglar he could have easily stopped escape, who then went on to murder Parker's beloved Uncle Ben, did Peter learn the lesson that "with great power there must also come great responsibility."
That is a line taken right from Spider-Man's first appearance in "Amazing Fantasy" #15, it does not get any more "original" than that. If you have read any of Spidey's hundreds of comic books, watched any of his cartoon series or any of the billion dollar grossing film franchise, you have heard that tagline, "with great power, comes great responsibility." This adage has become synonymous with the character. The death of his uncle rocked Peter and his family to their foundation and forever altered the course of his life. Leading to a lifetime of heroism. As a result, any other "sin," can not be anywhere near as significant as Peter Parker's true original sin.