"Call me crazy, but I've never really understood our culture's fear of getting older," said Winfrey. "The way I see it, every year can be a brand new journey. Think about it: You get one chance to be 25, 38, 44, 61 and every age before and between. Why wouldn't you want to experience all the wonder in each step on your path?"
'Be Grateful For Your Health and Body'
Oprah said instead of lamenting that you're 40 or 50 or 60, you should be grateful for whatever level of good health you have and appreciate the life's journey your body has brought you on.
"One day I literally woke up and thought 'These knees have been with me for 60 years,'" she said. "Wow! I've had these elbows for 60 years. My heart has been beating for 60 years. The feet I stand on have carried me for 60 years.' And when you think about it that way, you can be nothing but grateful."
Oprah, who has overcome childhood sexual abuse, a teenage pregnancy and years of weight fluctuations and diet frustration, said she has acquired a new appreciation for her body because she is healthy and well. Looking back, Winfrey regrets that she spent so much time and effort trying to be a certain size that she took her good health for granted.
"All the years I dieted, complained, and was less than satisfied with my shape have yielded to a new perspective, an appreciation for the body that's brought me this far," she said. "I've spent too many years resisting, neglecting and negating my body."
'Don't Sweat the Small Stuff'
Winfrey, who once tipped the scales at 237 pounds, follows an organic diet that features plenty of fruits, vegetables, fish, chicken and meat.
Oprah also exercises every day, doing 45 minutes of cardio exercise six days a week, combined with 40-minute strength-training workouts four or five days a week, said her trainer Bob Greene, author of The Best Life Diet Cookbook.
Winfrey, a self-professed emotional overeater and carb addict, no longer worries about being model-thin, but about being strong and vibrant. As she moves through her sixth decade, Oprah loves the wisdom and life lessons she has acquired over the decades.
She said her biggest regret is having wasted time worrying about silly things. She realizes now that the present is all we have, and we should fully embrace it instead of wistfully hoping for things to be a certain way.
"The absolute best part [of being 60] is being able to be free and do whatever you want," said Winfrey. "The hardest part is really recognizing the time that you've wasted and the things that you worried about that really didn't matter."
The self-made billionaire shared her secrets for happiness and success in her memoir, O's Big Book of Happiness.