The long-time rivals will play at Yankee Stadium and will wear a special ribbon on their uniforms during the game.
Yankees co-owner Hal Steinbrenner issued a press release on March 20, 2013 about the opening day game, stating, "Before baseball's greatest rivalry heats up for another season, the Yankees and Red Sox will stand together for Newtown ... we will reflect upon more important things and play the game to honor the community of Newtown."
According to the New York Daily News, the ribbon that the players will wear on April 1 will also be painted on the field in front of the dugouts for both teams.
A ceremony prior to the game will feature Newtown police and firefighters, a moment of silence. All 26 of the Sandy Hook victims' names will be posted on the video board at center-field at Yankee Stadium.
Red Sox owner John W. Henry also commented on the memorial scheduled for April 1.
"Months have passed, yet we are still trying to come to grips with this incomprehensible tragedy. As our teams look to face each other on Opening Day, we will stand united in support of the families affected as we remember and honor those who were lost."
After the announcement was made about the Yankees and the Red Sox honoring the Sandy Hook School victims on Opening Day, MLB commissioner Bud Selig asked that other teams due the same and wear a Newtown ribbon during their opening day games.