Lindner Family Tennis Center in Cincinnati, Ohio, will be the site for this terrific Serbia vs. United States showdown, slated for 1 p.m. ET (12 p.m. CT) on ESPN-2.
Djokovic and Isner will serve things off following the conclusion of the other quarter-finals between seventh-seeded Argentine, Juan Martin Del Potro and Russian qualifier, Dmitry Tursunov at 11 a.m. ET.
Check out the ATP's live stream page for more information on how you can watch these quarter-final Cincinnati Masters 2013 men's singles matches.
Because they're on the same side of the draw, the winners from each one of those matches will then meet in the semi-finals of the Cincinnati Masters 2013 on Saturday.
Djokovic holds a 3-1 lead over Isner in their head-to-head series, while Del Potro defeated Tursunov in their only meeting in 2011.
As expected, Djokovic [-800] is a huge favorite over Isner [+475] and Del Potro [-400] should be able to get past Tursunov [+275], to set up a must-see live stream semi-final in before the 2013 US Open.