One of the big secrets about many of the qualifications companies list in job postings is that they don't always matter. One of the many things I have learned in my twenty-five years as a Headhunter and corporate recruiters, qualifications are in the eye of the beholder. This fact is most true when it comes to the college degree.
There is no doubt that many employers adhere strictly to the policy of not hiring a candidate who doesn't have the degree they require, however, just as many, if not more only use that criteria as a means of limiting the number of resumes or applications they might receive.
The bottom line is - if a candidate has the work experience, they will be considered for the job regardless of whether they have earned a college degree or not.
My advice to job seekers - unless the position is something highly professional which legally requires a degree or other certification like doctor, or lawyer, etc. it won't hurt you to apply for the job you are otherwise qualified for.
There is a very good chance an employer looking for actual work experience will consider you and hire you. There is a good chance your resume will make past the applicant tracking system filters.