"Killing Kennedy," based on the book of the same name by Bill O'Reilly and Martin Dugard, will premiere on Sunday, Nov. 10, just 12 days before the 50th anniversary of the assassination.
Rob Lowe portrays slain president John F. Kennedy, with Ginnifer Goodwin ("Once Upon a Time") as his wife Jacqueline. Produced by Ridley Scott, the film also stars Will Rothhaar and Michelle Trachtenberg as Lee Harvey and Marina Oswald.
The TV movie follows Kennedy and Oswald in the final years of both their lives. A newly released trailer for the telepic gives viewers their first glimpse of the actors in their respective roles, with Lowe making a somber speech as Kennedy from behind a podium while delivering his best Massachusetts accent.
The cable network's first original movie, "Killing Lincoln," also based on a book by O'Reilly and Dugard, debuted in February to 3.4 million viewers, making it the most-watched program in NatGeo's history.