Mithridates VI, also known as the poison King, because of his fear of being poisoned. He doctored himself with poison on a daily basis, which he believed would make him immune, if he were given poison. This is a king who opposed the Roman influence; he was given the title Eupator which translates to being born from a noble father. He also became known as Megas or the great. Mithridates came from a long list of influential people he himself claimed to be a descendent of King Darius I and Alexander the great. He had direct links with the Seleucid Kingdom because he was raised in Pontus. King Mithridates V rule before him and was poisoned in 120 B. C. in the city of Sinope at a banquet. Their mother Laodice VI was temporarily in charge of the country because of the tender age of her two sons to whom the kingdom would pass. She ruled from 120 – 116 B. C. It became a well-known fact that her son is Mithrdates was not her chosen favorite she preferred Chrestus, causing Mithridates to go into hiding to avoid being killed by his mother.
Mithridates returned to Pontus around 116 B.C. and took the throne that his mother and brother had ruled together as co-regents. After he became king he had both his mother and brother placed into prison. His mother died in prison of natural causes, his brother also died in prison but there's no record indicating if it was by natural causes or to execution. King Mithridates gave a royal funeral to both mother and brother. He had an older sister who was 16 years of age that he took as his wife immediately following the funeral. He did this in order to assure a succession for legitimate children and follow the royal bloodline.
Mithridates became obsessed with the idea that he would be assassinated through the common use of poison. Poisoning had been a means of assassination for thousands of years, because of this he put himself on a very rigid schedule for taking medicine that he concocted up that was lethal. He was so dedicated to this project that he studied anything that he could find as well as discussing procedures with advisers that he trusted. This practice today is known as Mithridatism, one good example of this would be snake handlers who work with various poisons in their unique field.
Mithridates decided that he wanted to expand his kingdom which led to his war with Rome. He battled with the Scythian King Palacus and after many battles the Scythians submitted and fell under his jurisdiction. His next battle was with King Nicomedes III of Bithynia when they had a disagreement over Cappadocia. After several defeats King Nicomedes III asked for the assistance of Rome. After many struggles with the new ruler Nicomedes VI, war was declared against Pontus and in 89 B.C. The kingdom of Pontus was invaded by the Roman legions. Mithdirates quickly defeated the Roman army and were warmly received by the citizens of Anatolia. Shortly thereafter Mithridates decided to kill any remaining Roman or Italian settlers who were in Anatolian cities, approximately 80,000 were wiped out. This massacre became known as the" Asiatic Vespers". There were many other wars that Mithridates fought against Rome and finally he took to residence in Bosporan. Mithridates wanted to again go to war against Rome and his son rejected the idea resulting in Mithridates killing his son and taking control of the Bosporan Kingdom. Finally Mithridates retreated to Panticapaeum where he was overtaken by the enemy. He decided he would take the noble way out and commit suicide by means of poison, however his attempt was unsuccessful. He did however succeed in committing suicide by ordering a mercenary to kill him with his sword. This act brought in the end to the great kingdom of Pontoc. The champion Gnaus Pompeius Strabo Magnus a Roman representative returned the body of the Mithridates VI, to Amasya to be buried in the rock – cut crypts of his family.