The Wild had outplayed all five of their opponents, including one previous road game, but the Sabres were able to have the advantage in shots on goal and made the game interesting late.
Jason Pominville broke a 1-1 for the game-winning goal with 9.7 remaining in the second period and one second remaining on the Wild's first power play opportunity of the game.
The Wild finished the game 1-3 on the power play and killed all four of their penalty kill chances.
The Sabres (0-6-1) tied the game with four minutes and 56 seconds remaining in the second period when Brian Flynn knocked the rebound off his own shot over arm and pad of a reaching Josh Harding.
Kyle Brodziak scored his first goal of the season off a pass from Matt Cooke five minutes and 23 seconds into the first period. Jonas Brodin also assisted on the goal to extend his point streak to three games.
The Wild (3-1-2) completed the first back-to-back games Tuesday at the Toronto Maple Leafs.
No. 3 – Kyle Brodziak. The Wild forward scored a goal.
No. 2 – Josh Harding. The Wild goaltender stopped 22 shots.
No. 1 – Jason Pomiville. The Wild forward scored a goal.
Minnesota…..1 1 0 – 2
Buffalo…..…..0 1 0 – 1
First Period – 1, Minnesota, Brodziak 1 (Cooke, Brodin), 5:23. Penalties – Dumba, MIN (interference), 5:40; Stoner, MIN, major (fighting), 11:27; McCormick, BUF, major (fighting), 11:27; Heatley, MIN (tripping), 12:13.
Second Period – 2, Buffalo, Flynn 1 (Girgensons), 15:04. 3, Minnesota, Pominville 2 (Koivu, Spurgeon), 19:50 (pp). Penalties – Parise, MIN (holding the stick), 11:31; Stafford, BUF (hooking), 17:51.
Third Period – None. Penalties – Stoner, MIN (roughing), 6:10; Tallinder, BUF (high sticking), 9:58; Bench, BUF (too many men; served by Vanek), 12:56.
Shots on goal – Minnesota 6-8-6 20. Buffalo 5-12-6 23.
Goalies – Minnesota, Harding (22-23). Buffalo, Enroth (18-20). Referees – Kyle Rehman, Chris Rooney. Linesmen – Lonnie Cameron, Steve Miller.