Arroyo (4-4) felt strange about making a start against his former team and was taken to task earlier. One of the few Reds (23-29) who were not teammates with the veteran right-hander, Skip Schumaker, notched the first hit off Arroyo in the first inning and that set the tone for the second inning.
Before the Reds could get to Arroyo, the Diamondbacks (23-34) got to Mike Leake (3-4). A.J. Pollock started the bottom of the first with a single, stole second, moved to third on a ground ball, then scored on a ground out by Paul Goldschmidt.
That lead was brief as Jay Bruce, Todd Fraizer, and Roger Bernadina each singled to start the second inning to load the bases for Devin Mesoraco. While not his usual catcher when starting for Cincinnati, Mesoraco faced his former battery mate for the first time in his career and promptly sent Arroyo's offering into the left field stands for a quick 4-1 lead. Arroyo even got a good look at Billy Hamilton, who singled, stole second, moved to third on a throwing error, but was stranded by Schumaker at third to end the big inning.
Leake allowed the Diamondbacks right in it during the third inning, although the Reds defense didn't help. Pollack made it to second on a throwing error by Fraizer which set up an RBI single by Gerado Parra. Frazier's poor fielding struck again as this time he allowed a run to score when his errant throw sent Goldschmidt to second and Parra home.
The scored remained 4-3 as both pitchers settled in over the next three innings, but were back to giving up runs in the sixth. After a one-out walk to Frazier, Bernadina made Arroyo pay with an RBI double, but kept the inning from getting too far out of hand when he was caught trying to steal third. Leake was victimized in the sixth when Aaron Hill singled home Goldschmidt to cut the lead to 5-4.
Sam LeCure and Jonathan Broxton pitched scoreless innings of relief, and Mesoraco hit a solo homer off Evan Marshall in the ninth to set up Aroldis Chapman. Chapman came on and got a ground out and two strikeouts of pinch-hitters to notch his sixth save of the season.
The Reds and Diamondbacks continue their four-game set on Saturday when Brandon McCarthy (1-6, 4.87 ERA) takes on Johnny Cueto (4-4, 1.83 ERA). Cueto is coming off his worst two outings of the season in which he has allowed 12 runs in 12.2 innings, but only seven of those were earned.