The Lobos (33-15-1, 16-8) got a solid start from Drew Bridges (3-1), his first since March. The sophomore threw 4.1 scoreless innings, allowing just three hits and two walks.
Alex Real went 4-for-4 with a run, two doubles and an RBI. Danny Collier was 3-for-4, while John Pustay and Aaron Siple each drove in three runs.
Victor Sanchez earned his eighth save as he pitched the final three innings. He gave up two runs, but only one was earned.
The Aztecs (32-16, 13-11) won the series opener Friday but lost the next two. Tim Zier and Tyler France each had three hits, while Brad Haynal hit a two-run homer, but it was not enough.
The Lobos will play a non-conference game against Utah Valley on Monday at 1 p.m. They will then travel to Nevada for a three-game series starting Friday night.