Nationwide: Busch was third in final practice and took the pole for the Bubba Burger 250. This was also Busch's first Nationwide pole of 2010 and third at Richmond. Busch led until lap 59, when Brad Keselowski passed him. During the caution on lap 96, Busch lost four spots when the crew had trouble with a lug nut. With 90 to go, he was stuck in fifth place. With 61 laps left, a caution came out and his crew stepped it up, bringing him out second. Busch took the lead after a caution with six laps left but having not gone on to pit road, he couldn't beat Keselowski and his new tires. He finished fourth.
Cup: Busch was in the top five in both practices, placing fifth and first. He kept his momentum going into qualifying, first with the Nationwide pole followed by the Cup pole. He started next to fellow Toyota driver David Reutimann. Busch quickly pulled away from the rest of the pack at the drop of the green flag. He kept his lead through the first caution and kept going, lapping cars and making his lead even bigger. On lap 171 he lost the lead to Ryan Newman after a caution for debris but he took it back quickly since Newman was on two tires while Busch was on four. On lap 230, he lost the lead to Jeff Burton, who was hungry for a win. On lap 242, Busch fell further back to third place, being passed by the other Jeff (Gordon). He still didn't know what was wrong with his car. With 100 laps left, he was in fourth place. With 25 to go, Busch was in sixth after a caution. After two more cautions and 12 to go, he was in second. On the restart, Busch got a jump on Gordon and took the checkered flag.
Busch was 11th and eighth in practices and started 16th. On lap 70, while his brother was leading the race, he had made his way up to 7th. Still without a caution, on lap 121 Busch was in 10th. After green flag pit stops, he was 16th. Before the halfway mark at lap 190, Busch was 15th. After more green flat pit stops around lap 265, he was in 22nd place. With 100 laps to go, he was still in the same position. With 25 to go, after a caution, he was 18th. With 12 to go after two more cautions, he was still 18th and finished the race in the same place.
Gaughan finished 12th in final practice and qualified 17th for the race. On lap 90, Gaughan was about to be lapped by the leader but needed to cool his brakes. If he chose to cool his brakes, he would slow down, guaranteeing being lapped down. Just a few laps later, on lap 96, he caught a break and got the Lucky Dog pass after being lapped by Brad Keselowski. On pit road, Gaughan's crew was nearly involved in a wreck with the car behind them during the pit stop. Gaughan raced consistently for the rest of the race and finished ninth and moved up three spots in the point standings.