Miguel Olivo's three-run double in the first inning put Albuquerque ahead for good in the second game.
Joc Pederson would later add his first career Triple-A home run, a solo shot in the fifth inning. He then drew a seventh inning walk, stole second base and third base and then scored on a sacrifice fly.
Olivo capped the scoring with an RBI single in the seventh.
Yimi Garcia (1-0) earned the win despite allowing two runs in two innings of relief work. Sam Demel earned the save with a scoreless seventh inning.
Starter Matt Magill gave up one run on four hits and two walks in four innings. He struck out three batters.
In the opener, starter Stephen Fife (0-1) struggled, allowing five runs on 10 hits and one walk in four innings. Reliever Steve Smith, a former UNM Lobo, then gave up another six runs in 1.1 innings.
Jamie Romak's solo home run was Albuquerque's lone offensive output in the opener.
The Isotopes and Rainiers will continue their series Saturday at 6:05 p.m. Dodgers pitching Zach Lee will start for Albuquerque in his Triple-A debut.
- Before Thursday's originally scheduled opener was rained out, the Isotopes made two roster changes. Right-hander Tyson Brummett was recalled from extended spring training to replace fellow reliever Jose Dominguez, who was called up by the Dodgers to replace the injured Brian Wilson.
- The other move saw the Isotopes add infielder Carlos Triunfel to the roster. The former Mariner was claimed off waivers by the Dodgers and optioned to Triple-A on Wednesday. To make room, infielder Ryan Adams was demoted to Double-A Chattanooga.
- Another roster move will have to be made when outfielder Mike Baxter reports to the Isotopes. He was demoted Friday after center fielder Matt Kemp was activated from the disabled list.