Back-to-back RBI singles by Shane Peterson and Nate Freiman, followed by a sacrifice fly, put Sacramento (63-49) ahead in the first inning. The River Cats would add runs in the fourth on an error and in the fifth on a bases-loaded walk.
Albuquerque (53-59) saw its bats go relatively silent again. Clint Robinson hit an RBI double in the third inning and Chone Figgins added an RBI single in the seventh.
Former Isotope Nick Buss added a two-run single in the seventh to cap the scoring for Sacramento. All of those runs proved to be more than enough.
Arnold Leon (10-5) allowed just the two runs on seven hits and two walks while striking out five in 6.1 innings. Three relievers combined to shut out Albuquerque the rest of the way.
Drew Carpenter (2-1) took the loss as he allowed five runs, four earned, on six hits and five walks in four-plus innings of work. Pedro Baez gave up the last two runs in 1.2 innings of relief.
Among the Isotopes' prospects, Joc Pederson was just 1-for-4 with a strikeout while Alex Guerrero was 0-for-4 with a strikeout. Guerrero played second base for the second game in a row.
Carlos Triunfel went 2-for-3 with a double, a triple and scored both Albuquerque runs. He has eight extra-base hits since being sent back down by the Dodgers on July 19.
The Isotopes and River Cats will continue their series Thursday at 8:05 p.m. Right-hander Zach Lee (6-9, 5.18 ERA) will start for Albuquerque against Sacramento right-hander Zach Neal (4-5, 4.63).
The Dodgers optioned veteran infielder Darwin Barney to Albuquerque on Wednesday. Barney was acquired from the Chicago Cubs in a trade for Single-A pitcher Jonathan Martinez. When Barney arrives the Isotopes will have to make a roster move. They currently have 14 pitchers and 11 position players.