Albuquerque (39-47) was being no-hit until the fifth inning of the opener until Griff Erickson singled to right field. Erickson stole second base and advanced to third on a wild pitch before Alex Liddi doubled to make it 1-0.
Erisbel Arruebarrena's RBI single made it 2-0, but the Isotopes were far from being done. Erickson blasted a two-run homer in the sixth inning and Johnny Monell then made it back-to-back homers for a 5-0 lead.
El Paso (41-46) nearly rallied in the bottom of the frame. Jonathan Galvez got the Chihuahuas started with a two-run homer.
Tyler Greene then tripled and Jeff Francouer followed with an RBI single. Four batters later, Rico Noel's RBI single pulled El Paso within one run.
With runners at second and third and just one out, former Isotope Alex Castellanos struck out and Jace Peterson, who started the inning with a walk, grounded out to end the threat. Jose Dominguez would retire the Chihuahuas in order in the seventh inning to earn his sixth save.
Starter Red Patterson tossed two scoreless innings before being pulled. Drew Carpenter (1-0) actually earned the victory in relief despite allowing all four El Paso runs.
Albuquerque led 4-2 in the second game before the Chihuahuas roared to life in the fifth inning. El Paso scored seven runs, capped by Cody Decker's three-run blast to left field.
Tim Federowicz went 2-for-4 with two RBI and Brian Cavazos-Galvez was 2-for-3 with a double and two RBI for the Isotopes. Francouer and Chris Nelson both went 3-for-3 for the Chihuahuas.
Matt Magill (4-4) took the loss in relief for the Isotopes, allowing six runs on four hits and two walks in 1.1 innings. Starter Carlos Frias gave up one run in three innings.
Albuquerque will go for the series victory over El Paso on Thursday at 7:05 p.m. Right-hander Stephen Fife (2-2, 5.83 ERA) will start for the Isotopes against the Chihuahuas' Chris Smith (0-0, 1.50).
The Los Angeles Dodgers acquired first baseman-outfielder Brock Peterson from the Washington Nationals organization for cash considerations on Tuesday. Peterson was assigned to the Isotopes on Wednesday. He was 1-for-3 with one run scored in the second game of the doubleheader. Last season, Peterson led the Pacific Coast League with 25 home runs while playing for Memphis (Cardinals). ... To make room for Peterson, outfielder Jeremy Hazelbaker was sent back to Double-A Chattanooga. Hazelbaker hit .222/.239/.433 with four home runs and 11 RBI in 22 games with Albuquerque.