While the 49ers were destroyed 29-3 against the Seattle on Sunday night, the bigger loss could be the injuries. Yes, this game was an insult and letdown, but it could be more hurting if anyone is out for a significant amount of time.
On the second defensive possession of the game, Ian Williams went down with a broken ankle after Seahawks OL J.R. Sweezy rolled underneath him. Williams was only making his second career start at the NT position. If Williams is out for a period of time, there is no true NT on the team with Glenn Dorsey and Demarcus Dobbs being "tweeners" who can play both DE and NT.
While Dorsey and Dobbs are adequate reserves, they are nowhere near to the level of Williams' production. Dorsey had a sack for the night, but proved to be ineffective at drawing double teams.
Eric Reid suffered a concussion when tackling Sidney Rice after a third down conversion. He appeared to be fine as he walked off the field, but he was sidelined for the game after the hit. This is a player that Trent Baalke and the 49ers invested in by trading up 13 spots and taken in the first round to replace Dashon Goldson, who was lost in free agency to Tampa Bay.
Craig Dahl was forced to step in for Reid and potentially C.J. Spillman could get playing time at the FS position. Reid showed promise as both a tackler and in coverage. He was good in the last line of defense tackling players and not letting opponents get passed him. Reid had an interception in both games he played.
Other players who didn't finish the game include Vernon Davis (hamstring) and Ray McDonald (unknown) in the fourth quarter. The good news is that McDonald's X-rays ended up being negative.
It's only week 2 of the season, but depending on what could happen, the 49ers will have to undergo changes on defense when the injuries are revealed.