Humphries, who won in the Swiss city that hosted the 1928 Olympic Winter Games and 1948 Olympic Winter Games, set a track record time of 4:30.31.
Anja Schneiderheinze and Lisette Thone of Germany won the silver medal, with Americans Elana Meyers and Katie Eberling finishing in third place.
For Humphries, the defending Olympic champion from the 2010 Olympic Winter Games, also won the 2012 Women' World Bobsled Championship in New York.
What has been remarkable about Humphries' performances is that she continues to win major international events with different brakewomen. She won her Olympic gold medal three years ago with Heather Moyse of Summerside, Prince Edward Island and won her World Championship last year with Jennifer Ciochetti of Edmonton.
Humphries will next compete February 15 in Sochi, Russia to close out the World Cup season.